Stroke is a fatal cerebral vascular disease with a high mortality rate and substantial
economic and social costs. ROS production and neuroinflammation have been implicated in …

Macrophages, the key cells of innate immunity, possess wide phenotypical and functional
heterogeneity. In vitro studies showed that microenvironment signals could induce the so …

Background Agomelatine has been shown to be effective in the treatment of depression, but
the molecular mechanisms underlying its antidepressant effects have yet to be elucidated …

The NKCC1 ion transporter contributes to the pathophysiology of common neurological
disorders, but its function in microglia, the main inflammatory cells of the brain, has remained …

Background Peripheral nerve injury (PNI) is a public health concern that results in sensory
and motor disorders as well as neuropathic pain and secondary lesions. Currently, effective …

Real‐time monitoring of neutrophil dynamics is crucial for timely diagnosis and effective
treatment of inflammation‐related diseases, which requires a reliable tracer for in vivo …

The pineal gland is a key player in surveillance and defense responses. In healthy
conditions, nocturnal circulating melatonin (MEL) impairs the rolling and adhesion of …

Methods: Directly after confirming the hyperglycemia, diabetic animals were treated with
insulin combined with PFC and were exposed to 2 stressors/day for 12 weeks. Then, four …

Here, we studied the neuroinflammation-and ischemia-related glial markers chitotriosidase
1 (CHIT1) and chitinase-3-like protein 1 (CHI3L1, alias YKL-40) in the human striate cortex …

В результате аналитического обзора многих клинических и экспериментальных
исследований установлены общие патогенетические механизмы развития …