Background: This systematic review summarizes the impact of pharmacogenetics on the
effect and safety of non-steroidal anti-inflammatory drugs (NSAIDs) and antidepressants …

The activity of cytochrome P450 enzymes is influenced by genetic and nongenetic factors;
hence, the metabolism of exogenous psychotropic medications and potentially some …

Primary headache disorders, such as migraine, tension-type headache (TTH), and cluster
headache, belong to the most common neurological disorders affecting a high percentage of …

In today's modern society, it seems to be more and more challenging to cope with life
stresses. The effect of psychological stress on emotional and physical health can be …

Purpose To investigate the suitability of microdosed oral omeprazole for predicting
CYP2C19 activity in vivo in combination with simultaneous assessment of CYP3A and …

The risk of infant exposure to dextromethorphan (DM) and its active metabolite, dextrorphan
(DX), through breast milk has not been evaluated. In this study, bound and unbound DM and …

This work is a review of the scientific evidence on the oral treatment of adult patients with
Gaucher disease type 1 (GD1) with a clinical guideline format according to the Agree II …

Doxepin, a tricyclic antidepressant (TCA), is widely used in the treatment of depressive
disorder and anxiety. There are some liquid chromatography-tandem mass spectrometry …

The discovery of haplotypes with unknown or uncertain function in the CYP2D6
pharmacogene is outpacing the capabilities of traditional in vitro and in vivo approaches to …

Pharmaceutical researchers are continually searching for techniques to improve both drug
development processes and patient outcomes. An area of recent interest is the potential for …