Global, regional, and national causes of under-5 mortality in 2000–19: an updated systematic analysis with implications for the Sustainable Development Goals

J Perin, A Mulick, D Yeung, F Villavicencio… - The Lancet Child & …, 2022 - thelancet.com
Background Causes of mortality are a crucial input for health systems for identifying
appropriate interventions for child survival. We present an updated series of cause-specific …

Neurodevelopment in Children Exposed to Zika in utero: Clinical and Molecular Aspects

L Schuler-Faccini, M Del Campo, A García-Alix… - Frontiers in …, 2022 - frontiersin.org
Five years after the identification of Zika virus as a human teratogen, we reviewed the early
clinical manifestations, collectively called congenital Zika syndrome (CZS). Children with …

Nervous system manifestations of arboviral infections

L Chauhan, E Matthews, AL Piquet… - Current Tropical …, 2022 - Springer
Abstract Purpose of Review Complex environmental factors and human intervention
influence the spread of arthropod vectors and the cycle of transmission of arboviruses. The …

Mortality from congenital Zika syndrome—nationwide cohort study in Brazil

ES Paixao, LL Cardim, MCN Costa… - … England Journal of …, 2022 - Mass Medical Soc
Abstract Background Prenatal exposure to Zika virus has potential teratogenic effects, with a
wide spectrum of clinical presentation referred to as congenital Zika syndrome. Data on …

microRNAs control antiviral immune response, cell death and chemotaxis pathways in human neuronal precursor cells (NPCs) during Zika virus infection

CM Polonio, P da Silva, FB Russo… - International Journal of …, 2022 - mdpi.com
Viral infections have always been a serious burden to public health, increasing morbidity
and mortality rates worldwide. Zika virus (ZIKV) is a flavivirus transmitted by the Aedes …

Characteristics of children of the Microcephaly Epidemic Research Group Pediatric Cohort who developed postnatal microcephaly

RCF Ramos, D de Barros Miranda-Filho… - Scientific reports, 2022 - nature.com
The number of studies published on postnatal microcephaly in children with Congenital Zika
Syndrome is small, clinical presentations vary and aspects of the evolution of these children …

Longitudinal follow-up of gross motor function in children with congenital Zika virus syndrome from a cohort in Rio de Janeiro, Brazil

T Hamanaka, CTM Ribeiro, S Pone, SC Gomes… - Viruses, 2022 - mdpi.com
Knowledge of how congenital Zika syndrome (CZS) impacts motor development of children
longitudinally is important to guide management. The objective of the present study was to …

Anthropometric parameters of children with congenital Zika virus exposure in the first three years of life

EB Aguiar, SM Pone, SCS Gomes Junior, FVM Soares… - Viruses, 2022 - mdpi.com
Little is known about the impact of congenital Zika virus (ZIKV) exposure on growth in the
first years of life. In this prospective cohort study, 201 ZIKV antenatally-exposed children …

ZIKV-envelope proteins induce specific humoral and cellular immunity in distinct mice strains

VAS Lunardelli, J de Souza Apostolico, HFS Souza… - Scientific Reports, 2022 - nature.com
Recent outbreaks of Zika virus (ZIKV) infection have highlighted the need for a better
understanding of ZIKV-specific immune responses. The ZIKV envelope glycoprotein (EZIKV) …

Proteomics of ZIKV infected amniotic fluids of microcephalic fetuses reveals extracellular matrix and immune system dysregulation

P Sosa‐Acosta, RD Melani… - PROTEOMICS …, 2022 - Wiley Online Library
During pregnancy, the vertical transmission of the Zika virus (ZIKV) can cause some
disorders in the fetus, called Congenital Zika Syndrome (CZS). Several efforts have been …