The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

Surgical resection remains the first line treatment for salivary gland cancer (SGC). In the
case of locally advanced disease, surgery is followed by adjuvant radiotherapy. Surgical …

Mutational signature analysis is commonly performed in cancer genomic studies. Here, we
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …

Lysine-specific demethylase 6A (KDM6A), also named UTX, is frequently mutated in bladder
cancer (BCa). Although known as a tumor suppressor, KDM6A's therapeutic potential in the …

Adenoid cystic carcinoma (ACC) is an aggressive salivary gland malignancy with limited
treatment options for recurrent or metastatic disease. Due to chemotherapy resistance and …

Salivary adenoid cystic carcinoma (ACC) is a rare, biologically unique biphasic tumor that
consists of malignant myoepithelial and luminal cells. MYB and Notch signaling have been …

Simple Summary Patients with adenoid cystic carcinoma (ACC) often experience late distant
metastasis years after definitive therapy, most commonly to the lungs. Currently, there is little …

Triple-negative breast cancers (TNBC) comprise biologically and clinically heterogeneous
diseases characterized by the lack of hormone receptors (HR) and HER2 expression. This …

Simple Summary Adenoid cystic carcinoma (ACC) is an aggressive glandular cancer with
poor prognosis that preferentially occurs in the head and neck. The MYB and MYBL1 …

Opinion statement Adenoid cystic carcinoma (ACC) is a heterogeneous cancer that
commonly develops in the salivary glands. Approximately 40 to 50% of patients with ACC …