Mitochondrial DNA repair in neurodegenerative diseases and ageing

V Bazzani, M Equisoain Redin, J McHale… - International Journal of …, 2022 - mdpi.com
Mitochondria are the only organelles, along with the nucleus, that have their own DNA.
Mitochondrial DNA (mtDNA) is a double-stranded circular molecule of~ 16.5 kbp that can …

Therapeutic applications of mitochondrial transplantation

O Ulger, GB Kubat - Biochimie, 2022 - Elsevier
This review aims to make a framework of exogenous healthy mitochondrial transplantation
and to assemble present information for improving new therapeutic applications in a variety …

[HTML][HTML] Mosaic dysfunction of mitophagy in mitochondrial muscle disease

T Mito, AE Vincent, J Faitg, RW Taylor, NA Khan… - Cell metabolism, 2022 - cell.com
Mitophagy is a quality control mechanism that eliminates damaged mitochondria, yet its
significance in mammalian pathophysiology and aging has remained unclear. Here, we …

The complicated nature of somatic mtDNA mutations in aging

M Sanchez-Contreras, SR Kennedy - Frontiers in aging, 2022 - frontiersin.org
Mitochondria are the main source of energy used to maintain cellular homeostasis. This
aspect of mitochondrial biology underlies their putative role in age-associated tissue …

Strategies to improve the efficiency of somatic cell nuclear transfer

K Srirattana, M Kaneda, R Parnpai - International Journal of Molecular …, 2022 - mdpi.com
Mammalian oocytes can reprogram differentiated somatic cells into a totipotent state through
somatic cell nuclear transfer (SCNT), which is known as cloning. Although many mammalian …

Physical fitness and its correlation with handgrip strength in active community-dwelling older adults

PJ Pan, NW Hsu, MJ Lee, YY Lin, CC Tsai, WS Lin - Scientific Reports, 2022 - nature.com
In this cross-sectional study, we assessed the physical fitness levels of active community-
dwelling older adults. Moreover, we investigated the correlation of their (stratified by age and …

Incidence and risk factors of metabolic syndrome among Royal Thai Army personnel

B Sakboonyarat, R Rangsin, MA Mittleman - Scientific Reports, 2022 - nature.com
Metabolic Syndrome is a clustering of obesity, hyperglycemia/insulin resistance,
dyslipidemia, and hypertension. We aimed to determine the incidence of metabolic …

Accurate age estimation from blood samples of Han Chinese individuals using eight high-performance age-related CpG sites

X Han, C Xiao, S Yi, Y Li, M Chen, D Huang - International Journal of Legal …, 2022 - Springer
Age-related CpG sites (AR-CpGs) are currently the most promising biomarkers for forensic
age estimation. In our previous studies, we first validated the age correlation of seven …

Dietary restriction modulates mitochondrial DNA damage and oxylipin profile in aged rats

AP Gureev, NV Andrianova, IB Pevzner… - The FEBS …, 2022 - Wiley Online Library
Age‐related impairment of coordination of the processes of maintaining mitochondrial
homeostasis is associated with a decrease in the functionality of cells and leads to …

Biochemical analyses for dental age estimation: a review

M Pillalamarri, R Manyam, S Pasupuleti… - Egyptian Journal of …, 2022 - Springer
Background For various legal and forensic scenarios, establishing an individual's age, both
living and dead, plays a crucial role. Various morphological, radiographic, and molecular …