BRAF inhibitor resistance in melanoma: mechanisms and alternative therapeutic strategies
J Zhong, W Yan, C Wang, W Liu, X Lin, Z Zou… - … Treatment Options in …, 2022 - Springer
Opinion statement Melanoma is caused by a variety of somatic mutations, and among these
mutations, BRAF mutation occurs most frequently and has routinely been evaluated as a …
mutations, BRAF mutation occurs most frequently and has routinely been evaluated as a …
Role of miRNA in melanoma development and progression
A Poniewierska-Baran… - International Journal of …, 2022 - mdpi.com
Melanoma is one of the most aggressive and progressive skin cancers. It develops from
normal pigment-producing cells known as melanocytes, so it is important to know the …
normal pigment-producing cells known as melanocytes, so it is important to know the …
Targeting the epigenome in malignant melanoma: Facts, challenges and therapeutic promises
I Anestopoulos, S Kyriakou, V Tragkola… - Pharmacology & …, 2022 - Elsevier
Malignant melanoma is the most lethal type of skin cancer with high rates of mortality.
Although current treatment options provide a short-clinical benefit, acquired-drug resistance …
Although current treatment options provide a short-clinical benefit, acquired-drug resistance …
CC chemokine ligand-2: a promising target for overcoming anticancer drug resistance
Z Shi, J Tu, Y Ying, Y Diao, P Zhang, S Liao, Z Xiong… - Cancers, 2022 - mdpi.com
Simple Summary Drug resistance is an obstacle to cancer therapy, and the underlying
mechanisms are still being explored. CC chemokine ligand-2 (CCL2) is one of the key …
mechanisms are still being explored. CC chemokine ligand-2 (CCL2) is one of the key …
Epigenetic Mechanisms Underlying Melanoma Resistance to Immune and Targeted Therapies
A Rubanov, P Berico, E Hernando - Cancers, 2022 - mdpi.com
Simple Summary Despite major recent therapeutic advances, melanoma remains the
deadliest form of skin cancer due to the capacity of melanoma cells to adapt to drug …
deadliest form of skin cancer due to the capacity of melanoma cells to adapt to drug …
[HTML][HTML] Genetic layout of melanoma lesions is associated with BRAF/MEK-targeted therapy resistance and transcriptional profiles
E Vergani, A Busico, M Dugo, A Devecchi… - Journal of Investigative …, 2022 - Elsevier
The genetic landscape of melanoma resistance to targeted therapy with small molecules
inhibiting BRAF and MEK kinases is still largely undefined. In this study, we portrayed in …
inhibiting BRAF and MEK kinases is still largely undefined. In this study, we portrayed in …
Current understanding of epigenetics role in melanoma treatment and resistance
M Karami Fath, A Azargoonjahromi, A Soofi… - Cancer cell …, 2022 - Springer
Melanoma is the most aggressive form of skin cancer resulting from genetic mutations in
melanocytes. Several factors have been considered to be involved in melanoma …
melanocytes. Several factors have been considered to be involved in melanoma …
Visual barcodes for clonal-multiplexing of live microscopy-based assays
T Kaufman, E Nitzan, N Firestein, MB Ginzberg… - Nature …, 2022 - nature.com
While multiplexing samples using DNA barcoding revolutionized the pace of biomedical
discovery, multiplexing of live imaging-based applications has been limited by the number of …
discovery, multiplexing of live imaging-based applications has been limited by the number of …
TGF-β, to target or not to target; to prevent thyroid cancer progression?
Thyroid cancer (TC) is a common endocrine cancer with a rising incidence. Current
treatment fails to eliminate aggressive thyroid tumours, prompting an investigation into the …
treatment fails to eliminate aggressive thyroid tumours, prompting an investigation into the …
T Cells and CDDO-Me Attenuate Immunosuppressive Activation of Human Melanoma-Conditioned Macrophages
GM Torres, H Yang, C Park, PA Spezza… - Frontiers in …, 2022 - frontiersin.org
Melanoma tumors are highly immunogenic, making them an attractive target for
immunotherapy. However, many patients do not mount robust clinical responses to targeted …
immunotherapy. However, many patients do not mount robust clinical responses to targeted …