Major depression represents a complex and prevalent psychological disease that is
characterized by persistent depressed mood, impaired cognitive function and complicated …

Human physiology is likely to have been selected for endurance physical activity. However,
modern humans have become largely sedentary, with physical activity becoming a leisure …

Cytosine methylation efficiently silences CpG-rich regulatory regions of genes and repeats
in mammalian genomes. To what extent this entails direct inhibition of transcription factor …

The appropriate coordination between epigenetic regulators is essential for spatial and
temporal regulation of gene expression and maintenance of cell identity. Cancer is a …

It is well known that certain non B-DNA structures, including G-quadruplexes, are key
elements that can regulate gene expression. Here, we explore the theory that DNA …

Ubiquitin-like containing plant homeodomain Ring Finger 1 (UHRF1) protein is recognized
as a cell-cycle-regulated multidomain protein. UHRF1 importantly manifests the …

Inflammatory bowel diseases (IBD) are chronic inflammatory disorders of the gastrointestinal
tract that encompass two main phenotypes, namely Crohn's disease and ulcerative colitis …

The aryl hydrocarbon receptor (AhR) mediates various cellular responses upon exposure to
exogenous and endogenous stress factors. In these responses, AhR plays a dual role as a …

The DNA of all living organisms is persistently damaged by endogenous reactions including
deamination and oxidation. Such damage, if not repaired correctly, can result in mutations …

Background Genetics studies in the porcine immune system have enhanced selection
practices for disease resistance phenotypes and increased the efficacy of porcine models in …