Inverse salt sensitivity of blood pressure: mechanisms and potential relevance for prevention of cardiovascular disease

RA Felder, JJ Gildea, P Xu, W Yue, I Armando… - Current hypertension …, 2022 - Springer
Abstract Purpose of Review To review the etiology of inverse salt sensitivity of blood
pressure (BP). Recent Findings Both high and low sodium (Na+) intake can be associated …

[HTML][HTML] Timing is everything: impact of development, ageing and circadian rhythm on macrophage functions in urinary tract infections

AS Wang, NJ Steers, AR Parab, F Gachon… - Mucosal …, 2022 - Elsevier
The bladder supports a diversity of macrophage populations with functional roles related to
homeostasis and host defense, including clearance of cell debris from tissue, immune …

Adding salt to foods and hazard of premature mortality

H Ma, Q Xue, X Wang, X Li, OH Franco, Y Li… - European heart …, 2022 - academic.oup.com
Aims We analyzed whether the frequency of adding salt to foods was associated with the
hazard of premature mortality and life expectancy. Methods and results A total of 501 379 …

Na+ is shifted from the extracellular to the intracellular compartment and is not inactivated by glycosaminoglycans during high salt conditions in rats

IM Thowsen, TV Karlsen, E Nikpey… - The Journal of …, 2022 - Wiley Online Library
Recently, studies have emerged suggesting that the skin plays a role as major Na+ reservoir
via regulation of the content of glycosaminoglycans and osmotic gradients. We investigated …

Genetic engineering of lymphangiogenesis in skin does not affect blood pressure in mouse models of salt-sensitive hypertension

IM Thowsen, T Reikvam, T Skogstrand… - …, 2022 - Am Heart Assoc
Background: Recent studies have indicated that sodium storage is influenced by
macrophages that secrete VEGF-C (vascular endothelial growth factor) during salt stress …

Effects of dietary app-supported tele-counseling on sodium intake, diet quality, and blood pressure in patients with diabetes and kidney disease

SJ Schrauben, A Inamdar, C Yule, S Kwiecien… - Journal of Renal …, 2022 - Elsevier
Objectives The aim of this study is to examine the effect of a telehealth intervention that used
a dietary app, educational website, and weekly dietitian tele-counseling on sodium intake …

[HTML][HTML] Does excess tissue sodium storage regulate blood pressure?

G Rossitto, C Delles - Current Hypertension Reports, 2022 - Springer
Abstract Purpose of Review The regulation of blood pressure is conventionally
conceptualised into the product of “circulating blood volume” and “vasoconstriction …

[HTML][HTML] Skin sodium and blood pressure regulation

JH Jhee, HC Park, HY Choi - Electrolytes & Blood Pressure: E & BP, 2022 - ncbi.nlm.nih.gov
Hypertension is a major public health concern due to its high prevalence and increased risk
of cardiovascular disease and mortality. Complex traits resulting from both genetic and …

Mechanisms of sodium‐mediated injury in cardiovascular disease: old play, new scripts

G Rossitto, C Delles - The FEBS Journal, 2022 - Wiley Online Library
There is a strong association between salt intake and cardiovascular diseases, particularly
hypertension, on the population level. The mechanisms that explain this association remain …

[HTML][HTML] Targeting the dietary Na: K ratio—considerations for design of an intervention study to impact blood pressure

DJ Baer, A Althouse, M Hermann, J Johnson… - Advances in …, 2022 - Elsevier
Despite medical, dietary, and lifestyle recommendations and drug advancements,
hypertension persists as among the most prevalent noncommunicable diseases in the US …