Heart disease and stroke statistics—2022 update: a report from the American Heart Association

CW Tsao, AW Aday, ZI Almarzooq, A Alonso… - Circulation, 2022 - Am Heart Assoc
Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

[HTML][HTML] Metabolomics in diabetic retinopathy: from potential biomarkers to molecular basis of oxidative stress

Q Jian, Y Wu, F Zhang - Cells, 2022 - mdpi.com
Diabetic retinopathy (DR), the leading cause of blindness in working-age adults, is one of
the most common complications of diabetes mellitus (DM) featured by metabolic disorders …

[PDF][PDF] Insights into modifiable risk factors of cholelithiasis: a Mendelian randomization study

L Chen, H Yang, H Li, C He, L Yang, G Lv - Hepatology, 2022 - Wiley Online Library
Abstract Background and Aims The risk factors of cholelithiasis have not been clearly
identified, especially for total cholesterol. Here, we try to identify these causal risk factors …

[HTML][HTML] Integrating polygenic risk scores in the prediction of type 2 diabetes risk and subtypes in British Pakistanis and Bangladeshis: A population-based cohort study

S Hodgson, QQ Huang, N Sallah… - PLoS …, 2022 - journals.plos.org
Background Type 2 diabetes (T2D) is highly prevalent in British South Asians, yet they are
underrepresented in research. Genes & Health (G&H) is a large, population study of British …

[HTML][HTML] Associations of genetically predicted fatty acid levels across the phenome: a mendelian randomisation study

L Zagkos, MJ Dib, R Pinto, D Gill, F Koskeridis… - PLoS …, 2022 - journals.plos.org
Background Fatty acids are important dietary factors that have been extensively studied for
their implication in health and disease. Evidence from epidemiological studies and …

[HTML][HTML] HNF1A mutations and beta cell dysfunction in diabetes

Y Miyachi, T Miyazawa, Y Ogawa - International journal of molecular …, 2022 - mdpi.com
Understanding the genetic factors of diabetes is essential for addressing the global increase
in type 2 diabetes. HNF1A mutations cause a monogenic form of diabetes called maturity …

Persistent organic pollutants and β-cell toxicity: a comprehensive review

MP Hoyeck, G Matteo… - American Journal …, 2022 - journals.physiology.org
Persistent organic pollutants (POPs) are a diverse family of contaminants that show
widespread global dispersion and bioaccumulation. Humans are continuously exposed to …

Machine learning-based models for gestational diabetes mellitus prediction before 24–28 weeks of pregnancy: A review

D Mennickent, A Rodríguez, M Farías-Jofré… - Artificial Intelligence in …, 2022 - Elsevier
Abstract Gestational Diabetes Mellitus (GDM) is a hyperglycemia state that impairs maternal
and offspring health, short and long-term. It is usually diagnosed at 24–28 weeks of …

[HTML][HTML] Mendelian randomization analyses in ocular disease: a powerful approach to causal inference with human genetic data

J Li, C Li, Y Huang, P Guan, D Huang, H Yu… - Journal of Translational …, 2022 - Springer
Ophthalmic epidemiology is concerned with the prevalence, distribution and other factors
relating to human eye disease. While observational studies cannot avoid confounding …

[HTML][HTML] Interaction of obesity polygenic score with lifestyle risk factors in an electronic health record biobank

HS Dashti, N Miranda, BE Cade, T Huang, S Redline… - BMC medicine, 2022 - Springer
Background Genetic and lifestyle factors have considerable effects on obesity and related
diseases, yet their effects in a clinical cohort are unknown. This study in a patient biobank …