Hydroxypropyl methylcellulose acetate succinate as an exceptional polymer for amorphous solid dispersion formulations: A review from bench to clinic
A Butreddy - European Journal of Pharmaceutics and …, 2022 - Elsevier
Amorphous solid dispersions (ASDs) are a proven system for achieving a supersaturated
state of drug, in which the concentration of drug is greater than its crystalline solubility. The …
state of drug, in which the concentration of drug is greater than its crystalline solubility. The …
[HTML][HTML] Amorphous solid dispersions: role of the polymer and its importance in physical stability and in vitro performance
Amorphous solid dispersions stabilized by one or more polymer (s) have been widely used
for delivering amorphous drugs with poor water solubilities, and they have gained great …
for delivering amorphous drugs with poor water solubilities, and they have gained great …
Stable amorphous solid dispersion of flubendazole with high loading via electrospinning
J Becelaere, E Van Den Broeck, E Schoolaert… - Journal of Controlled …, 2022 - Elsevier
In this work, an important step is taken towards the bioavailability improvement of poorly
water-soluble drugs, such as flubendazole (Flu), posing a challenge in the current …
water-soluble drugs, such as flubendazole (Flu), posing a challenge in the current …
Mechanisms and extent of enhanced passive permeation by colloidal drug particles
Formulations containing nanosized drug particles such as nanocrystals and nanosized
amorphous drug aggregates recently came into light as promising strategies to improve the …
amorphous drug aggregates recently came into light as promising strategies to improve the …
Phase separation in surfactant-containing amorphous solid dispersions: Orthogonal analytical methods to probe the effects of surfactants on morphology and phase …
Amorphous–amorphous phase separation (AAPS) is an important phase transition process
for amorphous solid dispersion (ASD) performance both in terms of drug release as well as …
for amorphous solid dispersion (ASD) performance both in terms of drug release as well as …
Recent advances in enhancement of dissolution and supersaturation of poorly water-soluble drug in amorphous pharmaceutical solids: A review
Q Shi, F Li, S Yeh, SM Moinuddin, J Xin, J Xu… - Aaps Pharmscitech, 2022 - Springer
Amorphization is one of the most effective pharmaceutical approaches to enhance the
dissolution and oral bioavailability of poorly water-soluble drugs. In recent years, amorphous …
dissolution and oral bioavailability of poorly water-soluble drugs. In recent years, amorphous …
Kinetic solubility improvement and influence of polymers on controlled supersaturation of itraconazole-succinic acid nano-co-crystals
Z Huang, S Staufenbiel, R Bodmeier - International Journal of …, 2022 - Elsevier
Nano-co-crystals enhance the solubility and dissolution rate of poorly soluble drugs. The
objective of this study was to obtain a better understanding of the dissolution process of …
objective of this study was to obtain a better understanding of the dissolution process of …
Forced solid-state oxidation studies of nifedipine-PVP amorphous solid dispersion
In the present study, the oxidative degradation behavior of nifedipine (NIF) in amorphous
solid dispersions (ASDs) prepared with poly (vinyl pyrrolidone)(PVP) with a short (K30) and …
solid dispersions (ASDs) prepared with poly (vinyl pyrrolidone)(PVP) with a short (K30) and …
Lopinavir-menthol co-crystals for enhanced dissolution rate and intestinal absorption
Lopinavir is an antiretroviral, antiparasitic agent and recently utilized in treatment of COVID-
19. Unfortunately, lopinavir exhibited poor oral bioavailability due to poor dissolution …
19. Unfortunately, lopinavir exhibited poor oral bioavailability due to poor dissolution …
Self-gelation involved in the transformation of resveratrol and piperine from a co-amorphous system into a co-crystal system
J Han, L Li, Q Yu, D Zheng, Y Song, J Zhang, Y Gao… - …, 2022 - pubs.rsc.org
Co-amorphous and co-crystal systems are attractive crystal-engineering strategies for poorly
soluble drugs. Intermolecular interactions between components play a key role in the …
soluble drugs. Intermolecular interactions between components play a key role in the …