The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

Biofilms are multicellular microbial aggregates that can be associated with host mucosal
epithelia in the airway, gut, and genitourinary tract. The host environment plays a critical role …

Question Cystic fibrosis (CF) is characterised by the accumulation of viscous adherent
mucus in the lungs. While several hypotheses invoke a direct relationship with cystic fibrosis …

The advent of Cystic fibrosis transmembrane receptor (CFTR) modulators in 2012 was a
critical event in the history of cystic fibrosis (CF) treatment. Unlike traditional therapies that …

Mucus covers all wet epithelia and acts as a protective barrier. In the airways of the lungs,
the viscoelastic mucus meshwork entraps and clears inhaled materials and efficiently …

Mucociliary clearance is a critical defense mechanism for the lungs governed by regionally
coordinated epithelial cellular activities, including mucin secretion, cilia beating, and …

Cystic fibrosis (CF) is characterized by abnormal transepithelial ion transport. However, a
description of CF lung disease pathophysiology unifying superficial epithelial and …

The fluid covering the surface of airway epithelia represents a first barrier against
pathogens. The chemical and physical properties of the airway surface fluid are controlled …

Background Mucus hyperconcentration in cystic fibrosis (CF) lung disease is marked by
increases in both mucin and DNA concentration. Additionally, it has been shown that half of …

Abstract Chronic type 2 (T2) inflammatory diseases of the respiratory tract are characterized
by mucus overproduction and disordered mucociliary function, which are largely attributed to …