Drug repositioning: Progress and challenges in drug discovery for various diseases
Y Hua, X Dai, Y Xu, G Xing, H Liu, T Lu, Y Chen… - European Journal of …, 2022 - Elsevier
Compared with traditional de novo drug discovery, drug repurposing has become an
attractive drug discovery strategy due to its low-cost and high efficiency. Through a …
attractive drug discovery strategy due to its low-cost and high efficiency. Through a …
Efficacy of chloroquine and hydroxychloroquine for the treatment of hospitalized COVID-19 patients: a meta-analysis
Aims: To evaluate the efficacy and safety of hydroxychloroquine/chloroquine, with or without
azithromycin, in treating hospitalized COVID-19 patients. Materials & methods: Data from …
azithromycin, in treating hospitalized COVID-19 patients. Materials & methods: Data from …
[HTML][HTML] In-line treatments and clinical initiatives to fight against COVID-19 outbreak
In December 2019, when the whole world is waiting for Christmas and New Year, the
physicians of Wuhan, China, are astounded by clusters of patients suffering from pneumonia …
physicians of Wuhan, China, are astounded by clusters of patients suffering from pneumonia …
Hydroxychloroquine and azithromycin used alone or combined are not effective against SARS-CoV-2 ex vivo and in a hamster model
Drug repositioning has been used extensively since the beginning of the COVID-19
pandemic in an attempt to identify antiviral molecules for use in human therapeutics …
pandemic in an attempt to identify antiviral molecules for use in human therapeutics …
Anti-Zika Virus Effects, Placenta Protection and Chemical Composition of Passiflora edulis Seeds Ethanolic Extract
Various beneficial biological activities have been reported for passion fruit (Passiflora
edulis), grown in tropical and subtropical regions. However, no study has yet demonstrated …
edulis), grown in tropical and subtropical regions. However, no study has yet demonstrated …
Drugs to limit Zika virus infection and implication for maternal-fetal health
Although the placenta has robust defense mechanisms that protect the fetus from a viral
infection, some viruses can manipulate or evade these mechanisms and disrupt physiology …
infection, some viruses can manipulate or evade these mechanisms and disrupt physiology …
Bridging-BPs: a novel approach to predict potential drug–target interactions based on a bridging heterogeneous graph and BPs2vec
Predicting drug–target interactions (DTIs) is a convenient strategy for drug discovery.
Although various computational methods have been put forward in recent years, DTIs …
Although various computational methods have been put forward in recent years, DTIs …
Finding a chink in the armor: Update, limitations, and challenges toward successful antivirals against flaviviruses
Flaviviruses have caused large epidemics and ongoing outbreaks for centuries. They are
now distributed in every continent infecting up to millions of people annually and may …
now distributed in every continent infecting up to millions of people annually and may …
Repurposing drugs targeting epidemic viruses
Highlights•Drug repurposing is a powerful strategy for discovering new indications for drugs
that are used in various clinical applications.•The repurposing drugs approach reduces the …
that are used in various clinical applications.•The repurposing drugs approach reduces the …
A review on the pharmacokinetic properties and toxicity considerations for chloroquine and hydroxychloroquine to potentially treat coronavirus patients
F Askarian, Z Firoozi, A Ebadollahi-Natanzi… - Toxicological …, 2022 - Springer
Abstract The SARS-CoV-2 virus, caused a novel emerged coronavirus disease, is growing
rapidly worldwide. Few studies have evaluated the efficacy and safety of Chloroquine (CQ) …
rapidly worldwide. Few studies have evaluated the efficacy and safety of Chloroquine (CQ) …