[HTML][HTML] Interleukin-33 (IL-33): A critical review of its biology and the mechanisms involved in its release as a potent extracellular cytokine

C Cayrol, JP Girard - Cytokine, 2022 - Elsevier
Abstract Interleukin-33 (IL-33), a member of the IL-1 family, is an alarmin cytokine with
crucial roles in tissue homeostasis and repair, type 2 immunity, allergic and non-allergic …

Food allergy and hypersensitivity reactions in children and adults—A review

SG Tedner, A Asarnoj, H Thulin… - Journal of internal …, 2022 - Wiley Online Library
Adverse reactions after food intake are commonly reported and a cause of concern and
anxiety that can lead to a very strict diet. The severity of the reaction can vary depending on …

[HTML][HTML] Alarmin cytokines as central regulators of cutaneous immunity

T Hasegawa, T Oka, S Demehri - Frontiers in Immunology, 2022 - frontiersin.org
Skin acts as the primary interface between the body and the environment. The skin immune
system is composed of a complex network of immune cells and factors that provide the first …

[HTML][HTML] Intestinal uptake and tolerance to food antigens

Y Xiong, G Xu, M Chen, H Ma - Frontiers in Immunology, 2022 - frontiersin.org
Food allergy is a growing concern due to its increasing world-wide incidence. Strict
avoidance of allergens is a passive treatment strategy. Since the mechanisms responsible …

Single-cell transcriptome profile of mouse skin undergoing antigen-driven allergic inflammation recapitulates findings in atopic dermatitis skin lesions

JM Leyva-Castillo, L Sun, SY Wu, S Rockowitz… - Journal of Allergy and …, 2022 - Elsevier
Background Allergic skin inflammation elicited in mice by epicutaneous (EC) sensitization
with antigen shares characteristics with human atopic dermatitis (AD). Objective We …

Treating allergies via skin–recent advances in cutaneous allergen immunotherapy

LD Nesovic, AK Shakya, HS Gill - Advanced drug delivery reviews, 2022 - Elsevier
Subcutaneous allergen immunotherapy has been practiced clinically for decades to treat
airborne allergies. Recently, the cutaneous route, which exploits the immunocompetence of …

Clinical manifestations of pediatric food allergy: A contemporary review

LJ Wang, SC Mu, MI Lin, TC Sung, BL Chiang… - Clinical Reviews in …, 2022 - Springer
Food allergies (FAs) are an emerging health care issue, and a “second wave of the allergy
epidemic” was named. There are extensive data that documented the prevalence rate as …

Food allergy-induced autism-like behavior is associated with gut microbiota and brain mTOR signaling

LH Cao, HJ He, YY Zhao, ZZ Wang, XY Jia… - Journal of Asthma …, 2022 - Taylor & Francis
Purpose Food allergy-induced autism-like behavior has been increasing for decades, but
the causal drivers of this association are unclear. We sought to test the association of gut …

[HTML][HTML] House dust mite exposure enhances immune responses to ovalbumin-induced intestinal allergy

J Lin, D Chen, L Guan, K Chang, D Li, B Sun… - Scientific Reports, 2022 - nature.com
House dust mites (HDM) are one of the important factors of airway allergic diseases, HDM
allergens can be detected in the human gut mucosa, which induces local inflammation and …

[HTML][HTML] Combined IgE neutralization and Bifidobacterium longum supplementation reduces the allergic response in models of food allergy

SB An, BG Yang, G Jang, DY Kim, J Kim, SM Oh… - Nature …, 2022 - nature.com
IgE is central to the development of allergic diseases, and its neutralization alleviates
allergic symptoms. However, most of these antibodies are based on IgG1, which is …