Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …

Aging is typified by a progressive decline in mitochondrial activity and stress resilience.
Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and …

Epigenetic changes associated with histone modifications play an important role in the
emergence and maintenance of the phenotype of various cancer types. In contrast to direct …

Despite the rapid advancement in the introduction of new drugs for cancer therapy, the
frequent emergence of drug resistance leads to disease progression or tumor recurrence …

Lysine benzoylation (Kbz) is a newly discovered protein post-translational modification
(PTM). This PTM can be stimulated by benzoate and contributes to gene expression …

Cancer is characterized by alterations that cause the over-proliferation of cells and
hyperactivation of signaling pathways. Alterations of signaling molecules dysregulate …

E1A binding protein (p300) and CREB binding protein (CBP) are two highly homologous
and multidomain histone acetyltransferases. These two proteins are involved in many …

Haemorrhage into the brain parenchyma can be devastating. This manifests as
spontaneous intracerebral haemorrhage (ICH) after head trauma, and in the context of …

Simple Summary Currently, genomic databases offer a vast amount of information on
mutational profiles and records of statistically significant genetic associations with diseases …

Background. Over the past few years, dramatic breakthroughs in the field of tumor
immunotherapy with immune checkpoint inhibitors (ICIs) have made a therapeutic revolution …