Prostate cancer (PC), the second most prevalent malignancy in men worldwide, has been
proven to depend on the aberrant activation of androgen receptor (AR) signaling. Long-term …

In order to proliferate in unfavourable conditions, cancer cells can take advantage of the
naturally occurring endoplasmic reticulum-associated unfolded protein response (UPR) via …

Resistance to second-generation androgen receptor (AR) antagonists such as enzalutamide
is an inevitable consequence in patients with castration-resistant prostate cancer (CRPC) …

Abstract Heat shock protein 90 (HSP90) is involved in the stabilization and activation of
oncoproteins, rendering it essential for oncogenic transformation. However, the HSP90 …

Hypoxia is a main feature of most solid tumors, but how melanoma cells under hypoxic
conditions exploit tumor microenvironment (TME) to facilitate tumor progression remains …

The rare capacity for heat shock protein 90 (Hsp90) chaperones to support almost the entire
cellular signaling network was viewed as a potential breakthrough to combat tumor …

Corynebacterium bovis is an opportunistic pathogen of the skin of immunodeficient mice and
is sensitive to oral antibiotics that reach therapeutic blood concentrations. However …

Four series of molecular hybrids (37 final products) of neo-tanshinlactone, a natural product
extracted from Salvia miltiorrhiza Bunge, and known PD-1/PD-L1 interaction inhibitors were …

Sorafenib is currently used to treat hepatocellular carcinoma (HCC). However, the
development of chemoresistance to sorafenib is a major limitation for sorafenib‑based …

HSP90 inhibitors can target many oncoproteins simultaneously, but none have made it
through clinical trials due to dose-limiting toxicity and induction of heat shock response …