Oxidative stress signaling mediated pathogenesis of diabetic cardiomyopathy

Z Tang, P Wang, C Dong, J Zhang… - … Medicine and Cellular …, 2022 - Wiley Online Library
As a serious cardiovascular complication, diabetic cardiomyopathy (DCM) refers to diabetes‐
related changes in myocardial structure and function, which is obviously different from those …

Energy substrate metabolism and oxidative stress in metabolic cardiomyopathy

Z Chen, ZX Jin, J Cai, R Li, KQ Deng, YX Ji… - Journal of Molecular …, 2022 - Springer
Metabolic cardiomyopathy is an emerging cause of heart failure in patients with obesity,
insulin resistance, and diabetes. It is characterized by impaired myocardial metabolic …

Curcumin attenuates ferroptosis‐induced myocardial injury in diabetic cardiomyopathy through the Nrf2 pathway

Z Wei, Q Shaohuan, K Pinfang… - Cardiovascular …, 2022 - Wiley Online Library
Diabetes causes lipid peroxide to accumulate within cardiomyocytes. Furthermore, lipid
peroxide buildup is a risk factor for ferroptosis. This study is aimed at examining whether …

Curcumin activates Nrf2/HO‐1 signaling to relieve diabetic cardiomyopathy injury by reducing ROS in vitro and in vivo

X Wu, X Zhou, S Lai, J Liu, J Qi - The FASEB Journal, 2022 - Wiley Online Library
The hallmark feature of Diabetes mellitus (DM) is hyperglycemia which can lead to excess
production of reactive oxygen species (ROS) in the myocardium, contributing to diabetic …

The role of mitochondrial abnormalities in diabetic cardiomyopathy

SA Dabravolski, NK Sadykhov, AG Kartuesov… - International Journal of …, 2022 - mdpi.com
Diabetic cardiomyopathy (DCM) is defined as the presence in diabetic patients of abnormal
cardiac structure and performance (such as left ventricular hypertrophy, fibrosis, and …

Interplay of oxidative stress and necrosis-like cell death in cardiac ischemia/reperfusion injury: a focus on necroptosis

A Adameova, C Horvath, S Abdul-Ghani, ZV Varga… - Biomedicines, 2022 - mdpi.com
Extensive research work has been carried out to define the exact significance and
contribution of regulated necrosis-like cell death program, such as necroptosis to cardiac …

KLF9 aggravates streptozotocin-induced diabetic cardiomyopathy by inhibiting PPARγ/NRF2 signalling

F Li, J Peng, H Feng, Y Yang, J Gao, C Liu, J Xu… - Cells, 2022 - mdpi.com
Aims: Krüppel-like Factor 9 (KLF9) is a transcription factor that regulates multiple disease
processes. Studies have focused on the role of KLF9 in the redox system. In this study, we …

[Retracted] Knockdown of miR‐372‐3p Inhibits the Development of Diabetic Cardiomyopathy by Accelerating Angiogenesis via Activating the PI3K/AKT/mTOR/HIF‐1α …

Z Han, D Zhao, M Han, R Zhang… - Oxidative Medicine and …, 2022 - Wiley Online Library
Background. DCM is the most common and malignant complication of diabetes. It is
characterized by myocardial dilatation, hypertrophy, fibrosis, ventricular remodeling, and …

Proteomic analysis suggests altered mitochondrial metabolic profile associated with diabetic cardiomyopathy

KP Gomes, AS Jadli, LGN de Almeida… - Frontiers in …, 2022 - frontiersin.org
Diabetic cardiomyopathy (DbCM) occurs independently of cardiovascular diseases or
hypertension, leading to heart failure and increased risk for death in diabetic patients. To …

[HTML][HTML] Mechanisms for the development of heart failure and improvement of cardiac function by angiotensin-converting enzyme inhibitors

SK Bhullar, AK Shah, NS Dhalla - Scripta Medica, 2022 - scindeks.ceon.rs
Angiotensin-converting enzyme (ACE) inhibitors, which prevent the conversion of
angiotensin I to angiotensin II, are well-known for the treatments of cardiovascular diseases …