Epithelial barriers, which include the gastrointestinal, respiratory, and genitourinary mucosa,
compose the body's front line of defense. Since barrier tissues are persistently exposed to …

Memory B cells (MBCs) protect the body from recurring infections. MBCs differ from their
naive counterparts (NBCs) in many ways, but functional and surface marker differences are …

Lung-resident memory B cells (MBCs) provide localized protection against reinfection in
respiratory airways. Currently, the biology of these cells remains largely unexplored. Here …

Barrier tissues are the primary site of infection for pathogens likely to cause future
pandemics. Tissue-resident lymphocytes can rapidly detect pathogens upon infection of …

BACKGROUND Immune dysfunction is the crucial cause in the pathogenesis of
inflammatory bowel disease (IBD), which is mainly related to lymphocytes (T or B cells, incl …

Ecto-5′-nucleotidase (CD73), the ectoenzyme that together with CD39 is responsible for
extracellular ATP hydrolysis and adenosine accumulation, regulates immune/inflammatory …

Vaccines that efficiently target severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2), the etiological agent for coronavirus disease (COVID-19), are the best means for …

Memory B cells (MBCs) are essential for maintaining long-term humoral immunity to
infectious organisms, including Plasmodium. MBCs are a heterogeneous population whose …

We have previously shown that the microRNA (miRNA) processor complex consisting of the
RNAse Drosha and the DiGeorge Critical Region (DGCR) 8 protein is essential for B cell …

Recovery from pneumococcal (Spn) pneumonia induces development of tissue resident
memory CD4+ TRM cells, BRM cells, and antibody secreting plasma cells in experienced …