Animal behavior is shaped by a variety of" internal states"—partially hidden variables that
profoundly shape perception, cognition, and action. The neural basis of internal states, such …

Transcriptomics has revealed that cortical inhibitory neurons exhibit a great diversity of fine
molecular subtypes,,,,–, but it is not known whether these subtypes have correspondingly …

Variation in an animal's behavioral state is linked to fluctuations in brain activity and
cognitive ability. In the neocortex, state-dependent circuit dynamics may reflect …

Stimulus-selective response plasticity (SRP) is a robust and lasting modification of primary
visual cortex (V1) that occurs in response to exposure to novel visual stimuli. It is readily …

During sleep, sensory stimuli rarely trigger a behavioral response or conscious perception.
However, it remains unclear whether sleep inhibits specific aspects of sensory processing …

A surprising finding of recent studies in mouse is the dominance of widespread movement-
related activity throughout the brain, including in early sensory areas. In awake subjects …

Behavioral states can influence performance of goal-directed sensorimotor tasks. Yet, it is
unclear how altered neuronal sensory representations in these states relate to task …

The brain exhibits distinct patterns of recurrent activity closely related to behavioral state.
The neural mechanisms that underlie state-dependent activity in the awake animal are …

Cholinergic neurons in the medial septum (MS) constitute a major source of cholinergic
input to the forebrain and modulate diverse functions, including sensory processing …

Background The degeneration of the cholinergic circuit from the basal forebrain to the
hippocampus contributes to memory loss in patients suffering from Alzheimer's disease …