emerging drug therapies in inflammatory bowel disease

LB Grossberg, K Papamichael… - Alimentary …, 2022 - Wiley Online Library
Background The landscape of inflammatory bowel disease (IBD) treatment is rapidly
expanding with the development of new therapeutic options. Aim To review the mechanisms …

[HTML][HTML] Guselkumab for the treatment of Crohn's disease: induction results from the phase 2 GALAXI-1 study

WJ Sandborn, GR D'Haens, W Reinisch, J Panés… - Gastroenterology, 2022 - Elsevier
Background & Aims Guselkumab, a selective p19 interleukin-23 antagonist, is approved for
the treatment of plaque psoriasis and psoriatic arthritis. This study evaluated the efficacy and …

Transferable immunoglobulin A–Coated Odoribacter splanchnicus in responders to fecal microbiota transplantation for ulcerative colitis limits colonic inflammation

SF Lima, L Gogokhia, M Viladomiu, L Chou, G Putzel… - Gastroenterology, 2022 - Elsevier
Background & Aims Fecal microbiota transplantation (FMT) is an emerging treatment
modality for ulcerative colitis (UC). Several randomized controlled trials have shown efficacy …

[HTML][HTML] Nutraceuticals for the treatment of IBD: current progress and future directions

QY Ban, M Liu, N Ding, Y Chen, Q Lin, JM Zha… - Frontiers in …, 2022 - frontiersin.org
Inflammatory bowel disease (IBD) is a chronic relapsing-remitting inflammatory disease of
the gastrointestinal tract. Patients are usually diagnosed in adolescence and early …

[HTML][HTML] Neurogenesis is disrupted in human hippocampal progenitor cells upon exposure to serum samples from hospitalized COVID-19 patients with neurological …

A Borsini, B Merrick, J Edgeworth, G Mandal… - Molecular …, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), represents an enormous new threat to our
healthcare system and particularly to the health of older adults. Although the respiratory …

[HTML][HTML] Current status of novel biologics and small molecule drugs in the individualized treatment of inflammatory bowel disease

YH Xu, WM Zhu, Z Guo - World Journal of Gastroenterology, 2022 - ncbi.nlm.nih.gov
Abstract Treatment strategies for inflammatory bowel disease (IBD) are rapidly evolving with
the development of biologics and small molecule drugs (SMDs). However, these drugs are …

[HTML][HTML] Immune signature of covid-19: In-depth reasons and consequences of the cytokine storm

P Niedźwiedzka-Rystwej, A Majchrzak… - International Journal of …, 2022 - mdpi.com
In the beginning of the third year of the fight against COVID-19, the virus remains at least still
one step ahead in the pandemic “war”. The key reasons are evolving lineages and …

[HTML][HTML] Cysteine protease of Clonorchis sinensis alleviates DSS-induced colitis in mice

X Xie, Z Wu, Y Wu, J Liu, X Chen, X Shi… - PLoS neglected …, 2022 - journals.plos.org
Background Currently, inflammatory bowel disease (IBD) has become a global chronic
idiopathic disease with ever-rising morbidity and prevalence. Accumulating evidence …

Inflammatory bowel disease: pathogenesis, diagnosis and current therapeutic approach

A Silaghi, VD Constantin, B Socea… - Journal of Mind and …, 2022 - scholar.valpo.edu
Inflammatory bowel disease is a group of conditions of unknown etiology, represented by
Crohn's disease and ulcerative colitis and characterized by the presence of intestinal wall …

Qingchang Wenzhong Decoction reduce ulcerative colitis in mice by inhibiting Th17 lymphocyte differentiation

S Xia, L Chen, Z Li, Y Li, Y Zhou, S Sun, Y Su, X Xu… - Phytomedicine, 2022 - Elsevier
Abstract Background Qingchang Wenzhong Decoction (QCWZD), a chinese herbal
prescription, is widely used for ulcerative colitis (UC). Nevertheless, the active ingredients …