The outcomes of older patients with acute myeloid leukaemia are inferior to their younger
counterparts, because, in part, of a more aggressive disease biology and poorer tolerance of …

Vitamin A is the first defined vitamin and is also known as an anti-inflammatory micronutrient.
Although the primary biological function is preservation of epithelial tissue integrity, vision …

The negative prognostic impact of internal tandem duplication of FLT3 (FLT3-ITD) in patients
with acute myeloid leukemia with mutated NPM1 (AML-NPM1) is restricted to those with a …

Background and objective The prognostic value of age and other non-hematological factors
in predicting outcomes in older patients with newly diagnosed acute myeloid leukemia …

Non-coding micro-RNA (miRNAs) regulate the protein expression responsible for cell
growth and proliferation. miRNAs also play a role in a cancer cells' response to drug …

RARA and RXRA contribute to myeloid maturation in both mice and humans, and deletion of
Rxra and Rxrb augments leukemic growth in mice. While defining the domains of RXRA that …

Introduction: The overall outcome of patients with refractory AML (rAML) remains poor.
Though allogeneic hematopoietic stem cell transplantation (allo-HSCT) is considered as the …

Reproducibility is not only essential for the integrity of scientific research but is also a
prerequisite for model validation and refinement for the future application of predictive …

The discovery and application of immune checkpoint inhibitors (ICIs) has revolutionized the
therapeutic landscape in oncology. This discovery culminated from the elegant body-of-work …