Natural products of medicinal plants: biosynthesis and bioengineering in post-genomic era

L Guo, H Yao, W Chen, X Wang, P Ye, Z Xu… - Horticulture …, 2022 - academic.oup.com
Globally, medicinal plant natural products (PNPs) are a major source of substances used in
traditional and modern medicine. As we human race face the tremendous public health …

Integrated view of plant metabolic defense with particular focus on chewing herbivores

D Wari, T Aboshi, T Shinya… - Journal of integrative plant …, 2022 - Wiley Online Library
Success of plants largely depends on their ability to defend against herbivores. Since
emergence of the first voracious consumers, plants maintained adapting their structures and …

Identification of WRKY transcription factors involved in regulating the biosynthesis of the anti-cancer drug camptothecin in Ophiorrhiza pumila

C Wang, X Hao, Y Wang, I Maoz, W Zhou… - Horticulture …, 2022 - academic.oup.com
Camptothecin is a chemotherapeutic drug widely used to treat various cancers. Ophiorrhiza
pumila is an ideal plant model for the study of camptothecin production, with various …

Transcriptomic analysis of genes related to alkaloid biosynthesis and the regulation mechanism under precursor and methyl jasmonate treatment in Dendrobium …

C Jiao, M Wei, H Fan, C Song, Z Wang… - Frontiers in Plant …, 2022 - frontiersin.org
Dendrobium officinale is both a traditional herbal medicine and a plant of high ornamental
and medicinal value. Alkaloids, especially terpenoid indole alkaloids (TIAs), with …

Capsicum leaves under stress: Using multi-omics analysis to detect abiotic stress network of secondary metabolism in two species

JJ Reimer, B Shaaban, N Drummen… - Antioxidants, 2022 - mdpi.com
The plant kingdom contains an enormous diversity of bioactive compounds which regulate
plant growth and defends against biotic and abiotic stress. Some of these compounds, like …

Comparative transcriptome analysis provides novel insights into the molecular mechanism of berberine biosynthesis in Coptis chinensis

XM Liu, JP Tan, SY Cheng, ZX Chen, JB Ye… - Scientia …, 2022 - Elsevier
Berberine is the primary medicinal component of Coptis chinensis, a perennial herb in
Ranunculaceae. It has pharmacological effects, such as clearing away heat and dampness …

Jasmonate-responsive transcription factors NnWRKY70a and NnWRKY70b positively regulate benzylisoquinoline alkaloid biosynthesis in lotus (Nelumbo nucifera)

J Li, Y Li, M Dang, S Li, S Chen, R Liu… - Frontiers in Plant …, 2022 - frontiersin.org
Lotus (Nelumbo nucifera) is a large aquatic plant that accumulates pharmacologically
significant benzylisoquinoline alkaloids (BIAs). However, little is known about their …

Interplay of transcription factors orchestrating the biosynthesis of plant alkaloids

RC Godbole, AA Pable, S Singh, VT Barvkar - 3 Biotech, 2022 - Springer
Plants produce a range of secondary metabolites primarily as defence molecules. A plant
has to invest considerable energy to synthesise alkaloids, and sometimes they are even …

[HTML][HTML] A lesion-mimic mutant of Catharanthus roseus accumulates the opioid agonist, akuammicine

F Li, S Bordeleau, KH Kim, J Turcotte, B Davis, L Liu… - Phytochemistry, 2022 - Elsevier
Catharanthus roseus is a medicinal plant that produces an abundance of monoterpenoid
indole alkaloids (MIAs), notably including the anticancer compounds vinblastine and …

Transcriptome Analysis of Stephania tetrandra and Characterization of Norcoclaurine-6-O-Methyltransferase Involved in Benzylisoquinoline Alkaloid Biosynthesis

K Li, X Chen, J Zhang, C Wang, Q Xu, J Hu… - Frontiers in Plant …, 2022 - frontiersin.org
Stephania tetrandra (S. Moore) is a source of traditional Chinese medicine that is widely
used to treat rheumatism, rheumatoid arthritis, edema, and hypertension. Benzylisoquinoline …