Contribution of specific ceramides to obesity-associated metabolic diseases

P Hammerschmidt, JC Brüning - Cellular and Molecular Life Sciences, 2022 - Springer
Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play
specialized regulatory roles in cellular metabolism depending on their characteristic fatty …

[HTML][HTML] An Evidence-Based Narrative Review of Mechanisms of Resistance Exercise–Induced Human Skeletal Muscle Hypertrophy

C Lim, EA Nunes, BS Currier, JC Mcleod… - Medicine and science …, 2022 - ncbi.nlm.nih.gov
Skeletal muscle plays a critical role in physical function and metabolic health. Muscle is a
highly adaptable tissue that responds to resistance exercise (RE; loading) by …

Weight loss and exercise differentially affect insulin sensitivity, body composition, cardiorespiratory fitness, and muscle strength in older adults with obesity: a …

AM Brennan, RA Standley, SJ Anthony… - The Journals of …, 2022 - academic.oup.com
Background Aging-related disease risk is exacerbated by obesity and physical inactivity. It is
unclear how weight loss and increased activity improve risk in older adults. We aimed to …

The lard works in mysterious ways: ceramides in nutrition-linked chronic disease

RJ Nicholson, MK Norris, AM Poss… - Annual review of …, 2022 - annualreviews.org
Diet influences onset, progression, and severity of several chronic diseases, including heart
failure, diabetes, steatohepatitis, and a subset of cancers. The prevalence and clinical …

Untargeted lipidomic analysis of plasma from obese women submitted to combined physical exercise

R San Martin, CFC Brandao, MVM Junqueira-Franco… - Scientific Reports, 2022 - nature.com
This study aimed to determine the changes of lipidome in obese women undergoing
combined physical exercise training. Fourteen adult women with obesity (mean BMI and …

High intramuscular triglyceride turnover rates and the link to insulin sensitivity: influence of obesity, type 2 diabetes and physical activity

JS Barrett, KL Whytock, JA Strauss… - Applied Physiology …, 2022 - cdnsciencepub.com
Large intramuscular triglyceride (IMTG) stores in sedentary, obese individuals have been
linked to insulin resistance, yet well-trained athletes exhibit high IMTG levels whilst …

Improved aerobic capacity and adipokine profile together with weight loss improve glycemic control without changes in skeletal muscle GLUT-4 gene expression in …

M Venojärvi, J Lindström, S Aunola, P Nuutila… - International journal of …, 2022 - mdpi.com
(1) Objective: The aim of this study was to clarify the role of adipokines in the regulation of
glucose metabolism in middle-aged obese subjects with impaired glucose tolerance in …

UCP1 knockin induces lipid dynamics and transcriptional programs in the skeletal muscles of pigs

Z Xu, W Chen, L Wang, W You, Y Wang… - Frontiers in cell and …, 2022 - frontiersin.org
Uncoupling protein 1 (UCP1), the hallmark protein responsible for nonshivering
thermogenesis in adipose tissue (especially brown adipose tissue) has regained …

[HTML][HTML] Three minutes of moderate-intensity stair walking improves glucose and insulin but not insulin sensitivity or total antioxidant capacity

J Moore, EM Bartholomae, K Ward… - Nutrition, Metabolism …, 2022 - Elsevier
Abstract Background and Aims This study examined the effect of moderate intensity stair
stepping exercise on the glycemic response, and antioxidant capacity (TAC) during an oral …

[HTML][HTML] Sex differences in factors associated with prediabetes in Korean adults

JS Ra - Osong Public Health and Research Perspectives, 2022 - ncbi.nlm.nih.gov
Objectives Identifying the factors associated with prediabetes is necessary for the early
detection and management of high-risk individuals with prediabetes. The purpose of this …