Targeting the adaptive immune system in depression: focus on T helper 17 cells
There is a vital need to understand mechanisms contributing to susceptibility to depression
to improve treatments for the 11% of Americans who currently suffer from this debilitating …
to improve treatments for the 11% of Americans who currently suffer from this debilitating …
Molecular mechanisms of immunosenescene and inflammaging: relevance to the immunopathogenesis and treatment of multiple sclerosis
O Perdaens, V Van Pesch - Frontiers in neurology, 2022 - frontiersin.org
Aging is characterized, amongst other features, by a complex process of cellular
senescence involving both innate and adaptive immunity, called immunosenescence and …
senescence involving both innate and adaptive immunity, called immunosenescence and …
Regulatory B cell repertoire defects predispose lung cancer patients to immune-related toxicity following checkpoint blockade
Checkpoint blockade with Pembrolizumab, has demonstrated durable clinical responses in
advanced non-small cell lung cancer, however, treatment is offset by the development of …
advanced non-small cell lung cancer, however, treatment is offset by the development of …
Human B-cell subset identification and changes in inflammatory diseases
RL Velounias, TJ Tull - Clinical and experimental immunology, 2022 - academic.oup.com
Our understanding of the B-cell subsets found in human blood and their functional
significance has advanced greatly in the past decade. This has been aided by the evolution …
significance has advanced greatly in the past decade. This has been aided by the evolution …
Autoantibodies in neuropsychiatric systemic lupus erythematosus (NPSLE): can they be used as biomarkers for the differential diagnosis of this disease?
E Manca - Clinical Reviews in Allergy & Immunology, 2022 - Springer
Systemic lupus erythematosus is a complex immunological disease where both
environmental factors and genetic predisposition lead to the dysregulation of important …
environmental factors and genetic predisposition lead to the dysregulation of important …
Multi-modal single-cell sequencing identifies cellular immunophenotypes associated with juvenile dermatomyositis disease activity
Juvenile dermatomyositis (JDM) is a rare autoimmune condition with insufficient biomarkers
and treatments, in part, due to incomplete knowledge of the cell types mediating disease …
and treatments, in part, due to incomplete knowledge of the cell types mediating disease …
B cell aberrance in lupus: the ringleader and the solution
YX Nie, L Zhao, X Zhang - Clinical reviews in allergy & immunology, 2022 - Springer
Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease with high
heterogeneity but the common characterization of numerous autoantibodies and systemic …
heterogeneity but the common characterization of numerous autoantibodies and systemic …
CD45RB glycosylation and Ig isotype define maturation of functionally distinct B cell subsets in human peripheral blood
Glycosylation of CD45RB (RB+) has recently been identified to mark antigen-experienced B
cells, independent of their CD27 expression. By using a novel combination of markers …
cells, independent of their CD27 expression. By using a novel combination of markers …
Proportion of B cell subsets and Nrf2 mediated redox regulation in systemic lupus erythematosus patients
P Gautam, J Kaushal, A Sharma, A Bhatnagar - Immunobiology, 2022 - Elsevier
Systemic lupus erythematosus (SLE) is characterized by expansion of autoreactive
lymphocytes and impaired management of oxidative stress. Nuclear factor (erythroid-derived …
lymphocytes and impaired management of oxidative stress. Nuclear factor (erythroid-derived …
Pattern recognition receptor ligand-induced differentiation of human transitional B cells
JKP McMillan, P O'Donnell, SP Chang - Plos one, 2022 - journals.plos.org
B cells represent a critical component of the adaptive immune response whose development
and differentiation are determined by antigen-dependent and antigen-independent …
and differentiation are determined by antigen-dependent and antigen-independent …