Clearance of variant Creutzfeldt–Jakob disease prions in vivo by the Hsp70 disaggregase system
The metazoan Hsp70 disaggregase protects neurons from proteotoxicity that arises from the
accumulation of misfolded protein aggregates. Hsp70 and its co-chaperones disassemble …
accumulation of misfolded protein aggregates. Hsp70 and its co-chaperones disassemble …
Pseudouridine-dependent ribosome biogenesis regulates translation of polyglutamine proteins during Drosophila oogenesis
Stem cells in many systems, including Drosophila germline stem cells (GSCs), increase
ribosome biogenesis and translation during terminal differentiation. Here, we show that …
ribosome biogenesis and translation during terminal differentiation. Here, we show that …
Mrj an Hsp40 family chaperone regulates the oligomerization of Orb2 and long-term memory
Orb2 the Drosophila homolog of Cytoplasmic polyadenylation element binding protein
(CPEB) forms prion-like oligomers. These oligomers consist of Orb2A and Orb2B isoforms …
(CPEB) forms prion-like oligomers. These oligomers consist of Orb2A and Orb2B isoforms …
Molecular and clinical determinants of pathogenic protein aggregation: modulation of polyglutamine diseases by molecular chaperones
EP Mattos - 2022 - research.rug.nl
Correct protein folding is essential for life, but in the complex cellular environment proteins
face many risks of misfolding and/or aggregating. Protein aggregation, especially of so …
face many risks of misfolding and/or aggregating. Protein aggregation, especially of so …
DNAJB6 and its substrates: connecting the dots
E Kuiper - 2022 - research.rug.nl
Our life expectancy has increased over the last decades, but higher age is associated with
more diseases. A frequent cause of age-related diseases is the formation of protein …
more diseases. A frequent cause of age-related diseases is the formation of protein …