Post-translational regulation of HMG CoA reductase
Y Jo, RA DeBose-Boyd - Cold Spring Harbor …, 2022 - cshperspectives.cshlp.org
3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is an endoplasmic reticulum
(ER)-localized integral membrane protein that catalyzes the rate-limiting step in the …
(ER)-localized integral membrane protein that catalyzes the rate-limiting step in the …
Lowering low-density lipoprotein cholesterol: from mechanisms to therapies
J Luo, JK Wang, BL Song - Life Metabolism, 2022 - academic.oup.com
Low-density lipoprotein (LDL) is the main carrier of cholesterol and cholesteryl ester in
circulation. High plasma levels of LDL cholesterol (LDL-C) are a major risk factor of …
circulation. High plasma levels of LDL cholesterol (LDL-C) are a major risk factor of …
Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain
Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is the rate-limiting enzyme in
cholesterol synthesis and target of cholesterol-lowering statin drugs. Accumulation of sterols …
cholesterol synthesis and target of cholesterol-lowering statin drugs. Accumulation of sterols …
[HTML][HTML] Revised model of the tissue factor pathway of thrombin generation: role of the feedback activation of FXI
HHS Lakshmanan, A Estonilo, SE Reitsma… - Journal of Thrombosis …, 2022 - Elsevier
Background Biochemical reaction networks are self‐regulated in part due to feedback
activation mechanisms. The tissue factor (TF) pathway of blood coagulation is a complex …
activation mechanisms. The tissue factor (TF) pathway of blood coagulation is a complex …
Synthesis, function, and regulation of sterol and nonsterol isoprenoids
R Faulkner, Y Jo - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Cholesterol, the bulk end-product of the mevalonate pathway, is a key component of cellular
membranes and lipoproteins that transport lipids throughout the body. It is also a precursor …
membranes and lipoproteins that transport lipids throughout the body. It is also a precursor …
The prognosis of lipid reprogramming with the HMG-CoA reductase inhibitor, rosuvastatin, in castrated Egyptian prostate cancer patients: Randomized trial
RM Karkeet, AN Zekri, MM Sayed-Ahmed, GM Sherif… - Plos one, 2022 - journals.plos.org
Aim The role of surgical castration and rosuvastatin treatment on lipid profile and lipid
metabolism related markers was evaluated for their prognostic significance in metastatic …
metabolism related markers was evaluated for their prognostic significance in metastatic …
Quantitative assessment of arsenite-induced perturbation of ubiquitinated proteome
Arsenic contamination in food and groundwater constitutes a public health concern for more
than 200 million people worldwide. Individuals chronically exposed to arsenic through …
than 200 million people worldwide. Individuals chronically exposed to arsenic through …