Recent research and development of DYRK1A inhibitors
L Zhao, X Xiong, L Liu, Q Liang, R Tong, X Feng… - Chinese Chemical …, 2022 - Elsevier
Dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) is an evolutionarily
conserved protein kinase belonging to the CMGC kinase family, which is closely related to …
conserved protein kinase belonging to the CMGC kinase family, which is closely related to …
DYRK1A regulates the bidirectional axonal transport of APP in human-derived neurons
Dyrk1a triplication in Down's syndrome and its overexpression in Alzheimer's disease
suggest a role for increased DYRK1A activity in the abnormal metabolism of APP. Transport …
suggest a role for increased DYRK1A activity in the abnormal metabolism of APP. Transport …
DYRK1a Inhibitor Mediated Rescue of Drosophila Models of Alzheimer's Disease-Down Syndrome Phenotypes
B Zhu, T Parsons, W Stensen… - Frontiers in …, 2022 - frontiersin.org
Alzheimer's disease (AD) is the most common neurodegenerative disease which is
becoming increasingly prevalent due to ageing populations resulting in huge social …
becoming increasingly prevalent due to ageing populations resulting in huge social …
Early appearance of dendritic alterations in neocortical pyramidal neurons of the Ts65Dn model of Down syndrome
B Uguagliati, F Stagni, M Emili, A Giacomini… - Developmental …, 2022 - karger.com
Down syndrome (DS), which is due to triplication of chromosome 21, is constantly
associated with intellectual disability (ID). ID can be ascribed to both neurogenesis …
associated with intellectual disability (ID). ID can be ascribed to both neurogenesis …
Molecular evolution of tubulins in diatoms
KV Khabudaev, DP Petrova, YD Bedoshvili… - International Journal of …, 2022 - mdpi.com
Microtubules are formed by α-and β-tubulin heterodimers nucleated with γ-tubulin. Tubulins
are conserved eukaryotic proteins. Previously, it was shown that microtubules are involved …
are conserved eukaryotic proteins. Previously, it was shown that microtubules are involved …
[PDF][PDF] DYRK1A haploinsufficiency affects the development of astroglia and oligodendroglia, and axonal conductivity in the brain
I Pijuan, E Balducci, C Soto-Sánchez, E Fernández… - 2022 - scholar.archive.org
Background: The correct development and activity of neurons and glial cells, and the
interplay between them, is necessary to establish proper brain connectivity. DYRK1A …
interplay between them, is necessary to establish proper brain connectivity. DYRK1A …