Recent advancements in poor graft function following hematopoietic stem cell transplantation

Y Man, Z Lu, X Yao, Y Gong, T Yang… - Frontiers in …, 2022 - frontiersin.org
Poor graft function (PGF) is a life-threatening complication that occurs after transplantation
and has a poor prognosis. With the rapid development of haploidentical hematopoietic stem …

Towards a personalized definition of prognosis in Philadelphia-negative myeloproliferative neoplasms

B Mora, F Passamonti - Current Hematologic Malignancy Reports, 2022 - Springer
Abstract Purpose of Review Philadelphia-negative myeloproliferative neoplasms (MPNs)
include polycythemia vera (PV), essential thrombocythemia (ET), prefibrotic (pre-), and overt …

The incidence, outcomes, and risk factors of secondary poor graft function in haploidentical hematopoietic stem cell transplantation for acquired aplastic anemia

F Lin, T Han, Y Zhang, Y Cheng, Z Xu, X Mo… - Frontiers in …, 2022 - frontiersin.org
Secondary poor graft function (sPGF) increases the risk of life-threatening complications
after hematopoietic stem cell transplantation (HSCT). The incidence, clinical outcomes, and …

How we manage myelofibrosis candidates for allogeneic stem cell transplantation

N Polverelli, M Farina, M D'Adda, E Damiani, L Grazioli… - Cells, 2022 - mdpi.com
Moving from indication to transplantation is a critical process in myelofibrosis. Most of
guidelines specifically focus on either myelofibrosis disease or transplant procedure, and …

Impact of molecular profiling on the management of patients with myelofibrosis

I Pastor-Galán, I Martín, B Ferrer… - Cancer Treatment …, 2022 - Elsevier
Myelofibrosis (MF) is a chronic myeloproliferative neoplasm (MPN) characterized by a highly
heterogeneous clinical course, which can be complicated by severe constitutional …

[HTML][HTML] Low-dose total body irradiation added to fludarabine and busulfan reduced-intensity conditioning reduces graft failure in patients with myelofibrosis

CW Freyer, DV Babushok, NV Frey, SI Gill… - … and Cellular Therapy, 2022 - Elsevier
Allogeneic hematopoietic cell transplantation (alloHCT) is indicated for patients with
intermediate-risk or high-risk myelofibrosis (MF) and remains the sole potential cure …

Innovative strategies to improve hematopoietic stem cell transplant outcomes in myelofibrosis

J Perram, DM Ross, D McLornan… - American Journal of …, 2022 - Wiley Online Library
Myelofibrosis (MF) is a clonal myeloproliferative neoplasm characterized by inflammation,
marrow fibrosis, and an inherent risk of blastic transformation. Hematopoietic allogeneic …

Improving allogeneic stem cell transplantation in myelofibrosis

N Gagelmann, N Kröger - International Journal of Hematology, 2022 - Springer
In this review, we will outline dimensions in which outcome of patients with myelofibrosis
undergoing curative treatment can be optimized: patient selection, transplant procedure, and …

Transplantation algorithm for myelofibrosis in 2022 and beyond

JC Hernández-Boluda, T Czerw - Best Practice & Research Clinical …, 2022 - Elsevier
Myelofibrosis (MF) is a chronic myeloproliferative neoplasm with a very heterogenous
clinical course. Median survival of patients with overt MF is close to 6 years, but with great …

[PDF][PDF] Targeting GARP: TGF-β1 complexes on Tregs for the immunotherapy of myeloproliferative neoplasms

J Devreux - 2022 - dial.uclouvain.be
Philadelphia-negative myeloproliferative neoplasms (MPNs) regroup hematological
malignancies arising from the clonal expansion of a hematopoietic stem cell (HSC) and lead …