Cancer microenvironment is critical for tumorigenesis and cancer progression. The
extracellular matrix (ECM) interacts with tumor and stromal cells to promote cancer cells …

In recent years, the biological role of changes in physical factors in carcinogenesis and
progression has attracted increasing attention. Matrix stiffness, also known as ECM stress, is …

Simple Summary Matrix stiffness is recognized as a critical factor in cancer progression.
Recent studies have shown that matrix stiffening is caused by the accumulation, contraction …

The development of most solid cancers, including pancreatic, breast, lung, liver, and ovarian
cancer, involves a desmoplastic reaction: a process of major remodeling of the extracellular …

Cancer research has been largely focused on the cellular and molecular levels of
investigation. Recent data show that not only the cell but also the extracellular matrix plays a …

The extracellular matrix (ECM) provides structural support and imparts a wide variety of
environmental cues to cells. In the past decade, a growing body of work revealed that the …

Patients with idiopathic pulmonary fibrosis (IPF) have a high risk of developing lung cancer
compared with the general population. The morbidity of lung cancer in IPF patient ranges …

Aberrant variations in angiogenesis have been observed in tumor tissues with abnormal
stiffness of extracellular matrix (ECM). However, it remains largely unclear how ECM …

Long-term inhalation of fine particulate matter (PM 2.5) can cause serious effects on the
respiratory system. It might be attributed to the fact that PM 2.5 could directly enter and …

Tumor necrosis factor α stimulated gene 6 (TSG-6), a 30-KD secretory protein, plays an
essential role in modulating inflammatory responses and extracellular matrix remodeling …