Diabetes mellitus and melatonin: Where are we?
Diabetes mellitus (DM) and diabetes-related complications are amongst the leading causes
of mortality worldwide. The international diabetes federation (IDF) has estimated 592 million …
of mortality worldwide. The international diabetes federation (IDF) has estimated 592 million …
Autophagy dysregulation in metabolic associated fatty liver disease: A new therapeutic target
CL Chen, YC Lin - International journal of molecular sciences, 2022 - mdpi.com
Metabolic associated fatty liver disease (MAFLD) is one of the most common causes of
chronic liver disease worldwide. To date, there is no FDA-approved treatment, so there is an …
chronic liver disease worldwide. To date, there is no FDA-approved treatment, so there is an …
Nobiletin mitigates hepatocytes death, liver inflammation, and fibrosis in a murine model of NASH through modulating hepatic oxidative stress and mitochondrial …
S Li, X Li, F Chen, M Liu, L Ning, Y Yan, S Zhang… - The Journal of …, 2022 - Elsevier
This study aimed to investigate the therapeutic effects of nobiletin (NOB) on nonalcoholic
steatohepatitis (NASH) and liver fibrosis in mice and to elucidate its underlying molecular …
steatohepatitis (NASH) and liver fibrosis in mice and to elucidate its underlying molecular …
SIRT6 promotes mitochondrial fission and subsequent cellular invasion in ovarian cancer
S Bandopadhyay, P Prasad, U Ray… - FEBS Open …, 2022 - Wiley Online Library
Ovarian cancer ranks fifth in terms of cancer mortality in women due to lack of early
diagnosis and poor clinical management. Characteristics like high cellular proliferation, EMT …
diagnosis and poor clinical management. Characteristics like high cellular proliferation, EMT …
Anti-inflammatory effects of melatonin in rats with induced type 2 diabetes mellitus
H Yapislar, E Haciosmanoglu, T Sarioglu… - Life, 2022 - mdpi.com
Introduction: Insulin resistance is associated with a pro-inflammatory state increasing the risk
for complications in patients with type 2 diabetes mellitus (T2DM). In addition to its …
for complications in patients with type 2 diabetes mellitus (T2DM). In addition to its …
Potential therapeutic approach of melatonin against omicron and some other variants of SARS-CoV-2
R Begum, ANM Mamun-Or-Rashid, TT Lucy… - Molecules, 2022 - mdpi.com
The Omicron variant (B. 529) of COVID-19 caused disease outbreaks worldwide because of
its contagious and diverse mutations. To reduce these outbreaks, therapeutic drugs and …
its contagious and diverse mutations. To reduce these outbreaks, therapeutic drugs and …
Antioxidant effects of irisin in liver diseases: mechanistic insights
Oxidative stress is a crucial factor in the development of various liver diseases. Irisin, a
metabolic hormone discovered in 2012, is mainly produced by proteolytic cleavage of …
metabolic hormone discovered in 2012, is mainly produced by proteolytic cleavage of …
Canagliflozin prevents lipid accumulation, mitochondrial dysfunction, and gut microbiota dysbiosis in mice with diabetic cardiovascular disease
Type 2 diabetes mellitus (T2DM) is associated with cardiovascular disease (CVD) and
sodium glucose cotransporter 2 inhibitors, as oral medications for T2DM treatment have …
sodium glucose cotransporter 2 inhibitors, as oral medications for T2DM treatment have …
The key roles of organelles and ferroptosis in Alzheimerʼs disease
HZ Long, Y Cheng, ZW Zhou, HY Luo… - Journal of …, 2022 - Wiley Online Library
Alzheimerʼs disease (AD), an age‐related neurodegenerative disease, is a striking global
health problem. Ferroptosis is a newly discovered form of cell death characterized by iron …
health problem. Ferroptosis is a newly discovered form of cell death characterized by iron …
[HTML][HTML] Propionate alleviates fatty acid–induced mitochondrial dysfunction, oxidative stress, and apoptosis by upregulating PPARG coactivator 1 alpha in hepatocytes
X Wang, M Zhu, JJ Loor, Q Jiang, Y Zhu, W Li… - Journal of Dairy …, 2022 - Elsevier
Reduced feed intake during the transition period renders cows unable to meet their energy
needs for maintenance and lactation, leading to a state of negative energy balance. Severe …
needs for maintenance and lactation, leading to a state of negative energy balance. Severe …