Basics of androgen synthesis and action

RN Elzenaty, T Du Toit, CE Flück - Best Practice & Research Clinical …, 2022 - Elsevier
Androgens are essential sex steroid hormones for both sexes. Testosterone (T) is the
predominant androgen in males, while in adult females, T concentrations are about 15-fold …

Life modifications and PCOS: old story but new tales

Y Gu, G Zhou, F Zhou, Q Wu, C Ma, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
Polycystic ovary syndrome (PCOS) is defined as a kind of endocrine and metabolic disorder
that affects female individuals of reproductive age. Lifestyle modifications, including diet …

Evidence-based hormonal, mutational, and endocrine-disrupting chemical-induced zebrafish as an alternative model to study PCOS condition similar to mammalian …

G Sudhakaran, A Guru, BHD Muthu, R Murugan… - Life Sciences, 2022 - Elsevier
Polycystic ovarian syndrome (PCOS) causes swollen ovaries in women at reproductive age
due to hormonal disorder with small cysts on the outer edges. The cause of the disorder is …

Resveratrol and markers of polycystic ovary syndrome: a systematic review of animal and clinical studies

S Shojaei-Zarghani, M Rafraf - Reproductive Sciences, 2022 - Springer
Polycystic ovary syndrome (PCOS) is a common disorder affecting childbearing-age women,
and is associated with reproductive and metabolic disturbances. The present study aimed to …

Overactivation of the androgen receptor exacerbates gravid uterine ferroptosis via interaction with and suppression of the NRF2 defense signaling pathway

M Hu, Y Zhang, L Lu, Y Zhou, D Wu… - FEBS …, 2022 - Wiley Online Library
The mechanisms through which the androgen‐dependent activation of the androgen
receptor (AR) regulates gravid uterine ferroptosis remain unknown. We show that while co …

Biomaterials as regenerative medicine in Poly Cystic Ovarian Syndrome (PCOS) treatment

N Chauhan, A Peter, S Soni, R Rawal, U Jain - Biochemical Engineering …, 2022 - Elsevier
Over the last few decades, biomaterials became excellent candidates for tissue engineering
applications. Several biomaterials including scaffolds and hydrogels have been reported in …

[HTML][HTML] Androgen excess increases food intake in a rat polycystic ovary syndrome model by downregulating hypothalamus insulin and leptin signaling pathways …

Y Liu, YC Xu, YG Cui, SW Jiang, FY Diao, JY Liu… - …, 2022 - karger.com
Background: Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic
disorder characterized by high androgen levels. The aim of this study was to evaluate the …

Intergenerational high-fat diet impairs ovarian follicular development in rodents: a systematic review and meta-analysis

VG Paula, G Vesentini, YK Sinzato… - Nutrition …, 2022 - academic.oup.com
Context Excessive consumption of high-fat diets has increased in the population over time
and is harmful to female fertility. Objective To investigate and discuss the effects of a high-fat …

Kelulut Honey Regulates Sex Steroid Receptors in a Polycystic Ovary Syndrome Rat Model

DAM Kamal, SF Ibrahim, A Ugusman… - International Journal of …, 2022 - mdpi.com
Reproductive and metabolic anomalies in polycystic ovary syndrome (PCOS) have been
associated with the dysregulation of sex steroid receptors. Kelulut honey (KH) has been …

Clinical characteristics of hyperandrogenism include hirsutism, polycystic ovary syndrome, and acne: association with psychiatric disease in women-a nationwide …

TM Wang, CH Chou, YL Lee, CH Chung… - … Journal of Women's …, 2022 - Taylor & Francis
Objective Previous studies have shown an increased in psychiatric disorders in women with
disorders associated with hyperandrogenism, but few nationwide cohorts have studied this …