[HTML][HTML] DNA methylation as a mediator of genetic and environmental influences on Parkinson's disease susceptibility: Impacts of alpha-Synuclein, physical activity …
SL Schaffner, MS Kobor - Frontiers in genetics, 2022 - frontiersin.org
Parkinson's disease (PD) is a neurodegenerative disorder with a complex etiology and
increasing prevalence worldwide. As PD is influenced by a combination of genetic and …
increasing prevalence worldwide. As PD is influenced by a combination of genetic and …
Environmental enrichment and the aging brain: is it time for standardization?
M Balietti, F Conti - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
Aging entails a progressive decline of cognitive abilities. However, since the brain is
endowed with considerable plasticity, adequate stimulation can delay or partially …
endowed with considerable plasticity, adequate stimulation can delay or partially …
Environmental enrichment mitigates PTSD-like behaviors in adult male rats exposed to early life stress by regulating histone acetylation in the hippocampus and …
H Xu, B Li, L Li, Z Fan, X Gong, L Wu, C Yan - Journal of psychiatric …, 2022 - Elsevier
Early life stress (ELS) can cause long-term changes in gene expression, affect cognition,
mood, and behavior, and increase susceptibility to post-traumatic stress disorder (PTSD) in …
mood, and behavior, and increase susceptibility to post-traumatic stress disorder (PTSD) in …
AAV‐mediated expression of secreted and transmembrane αKlotho isoforms rescues relevant aging hallmarks in senescent SAMP8 mice
J Roig‐Soriano, C Griñán‐Ferré… - Aging cell, 2022 - Wiley Online Library
Senescence represents a stage in life associated with elevated incidence of morbidity and
increased risk of mortality due to the accumulation of molecular alterations and tissue …
increased risk of mortality due to the accumulation of molecular alterations and tissue …
[HTML][HTML] Environmental stimulation in Huntington disease patients and animal models
A Novati, HP Nguyen, J Schulze-Hentrich - Neurobiology of Disease, 2022 - Elsevier
While Huntington disease (HD) is caused solely by a polyglutamine expansion in the
huntingtin gene, environmental factors can influence HD onset and progression. Here, we …
huntingtin gene, environmental factors can influence HD onset and progression. Here, we …
[HTML][HTML] m6A Modification Involves in Enriched Environment-Induced Neurogenesis and Cognition Enhancement
W Qu, Q Li, M Wang, X Zhao, J Wu, D Liu… - Frontiers in Cell and …, 2022 - frontiersin.org
Although previous studies have shown that an enriched environment (EE) promotes
neurogenesis and alters DNA and histone modifications, it remains largely unknown …
neurogenesis and alters DNA and histone modifications, it remains largely unknown …
[HTML][HTML] 'Arc'-hitecture of normal cognitive aging
C Myrum, P Moreno-Castilla, PR Rapp - Ageing research reviews, 2022 - Elsevier
Arc is an effector immediate-early gene that is critical for forming long-term memories. Since
its discovery 25 years ago, it has repeatedly surprised us with a number of intriguing …
its discovery 25 years ago, it has repeatedly surprised us with a number of intriguing …
[PDF][PDF] AAV-mediated expression of secreted and transmembrane Klotho isoforms rescues relevant aging hallmarks in senescent SAMP8 mice
J Roig-Soriano, C Griñán-Ferré, JF Espinosa-Parrilla… - 2022 - klogenix.com
Senescence represents a stage in life associated with elevated incidence of morbidity and
increased risk of mortality due to the accumulation of molecular alterations and tissue …
increased risk of mortality due to the accumulation of molecular alterations and tissue …