Anesthetic agents disrupt neurodevelopment in animal models, but evidence in humans is
mixed. The morphologic and behavioral changes observed across many species predicted …

Numerous animal models have been used to study developmental neurotoxicity associated
with short-term or prolonged exposure of common general anesthetics at clinically relevant …

Ovarian cancer G-protein-coupled receptor 1 (OGR1, also known as GPR68) is a member of
proton-sensing G-protein-coupled receptors, involved in cardiovascular physiology, tumor …

Preclinical models demonstrate that nearly all anesthetics cause widespread
neuroapoptosis in the developing brains of infant rodents and non-human primates …

Neonatal anesthesia, while often essential for surgeries or imaging procedures, is
accompanied by significant risks to redox balance in the brain due to the relatively weak …

Despite the widespread use of oxytocin for induction of labor, mechanistic insights into
fetal/neonatal wellbeing are lacking because of the absence of an animal model that …

Concerns about the safety of anesthetic agents in children arose after animal studies
revealed disruptions in neurodevelopment after exposure to commonly used anesthetic …

Nonobstetric surgery may be required in up to 1% of pregnancies. Most common procedures
are urgent abdominal surgeries requiring general anaesthesia. Maintaining normal maternal …

The potential anesthetic neurotoxicity on the neonate is an important focus of research
investigation in the field of pediatric anesthesiology. It is essential to understand how these …

Background If anaesthetics cause permanent cognitive deficits in some children, the
implications are enormous, but the molecular causes of anaesthetic-induced neurotoxicity …