The morbidity and mortality of hepatic fibrosis caused by various etiologies are high
worldwide, and the trend is increasing annually. At present, there is no effective method to …

Background Liver fibrosis is a major disease that threatens people's health around the
world. However, there is a lack of effective treatment to completely reverse liver fibrosis …

Liver fibrosis is a wound-healing response that results from various chronic damages. If the
causes of damage are not removed or effective treatments are not given in a timely manner …

Objective and aims: Osteopontin (OPN), an oxidant stress sensitive cytokine, plays a central
role in liver fibrosis. While OPN expression can be reduced by small interfering RNA …

Cancer-associated fibroblasts (CAFs) are a major component of the tumor microenvironment
(TME). In hepatocellular carcinoma (HCC), quiescent hepatic stellate cells (HSCs) could be …

Abstract N6-methyladenosine (m 6 A) is the reversible epigenetic modification of mRNA
biogenesis. However, its potential role in HSCs activation and liver fibrosis remains poorly …

Male reproductive system ageing is closely associated with deficiency in testosterone
production due to loss of functional Leydig cells, which are differentiated from stem Leydig …

Hepatic fibrosis is a major global health problem and considered a leading cause of liver‐
related morbidity and mortality worldwide. Although previous studies have suggested that …

Liver fibrosis is a leading contributor to chronic liver diseases such as cirrhosis and liver
cancer, which pose a serious health threat worldwide, and there are no effective drugs to …

Purpose To clarify the underlying regulatory mechanisms of progression from liver cirrhosis
to hepatocellular carcinoma (HCC), we analyzed the microbiomics, metabolomics, and …