Statistics or biology: the zero-inflation controversy about scRNA-seq data
Researchers view vast zeros in single-cell RNA-seq data differently: some regard zeros as
biological signals representing no or low gene expression, while others regard zeros as …
biological signals representing no or low gene expression, while others regard zeros as …
Recent developments in application of single-cell RNA sequencing in the tumour immune microenvironment and cancer therapy
The advent of single-cell RNA sequencing (scRNA-seq) has provided insight into the tumour
immune microenvironment (TIME). This review focuses on the application of scRNA-seq in …
immune microenvironment (TIME). This review focuses on the application of scRNA-seq in …
Ultra‐high sensitivity mass spectrometry quantifies single‐cell proteome changes upon perturbation
AD Brunner, M Thielert, C Vasilopoulou… - Molecular systems …, 2022 - embopress.org
Single‐cell technologies are revolutionizing biology but are today mainly limited to imaging
and deep sequencing. However, proteins are the main drivers of cellular function and in …
and deep sequencing. However, proteins are the main drivers of cellular function and in …
Comparison and evaluation of statistical error models for scRNA-seq
S Choudhary, R Satija - Genome biology, 2022 - Springer
Background Heterogeneity in single-cell RNA-seq (scRNA-seq) data is driven by multiple
sources, including biological variation in cellular state as well as technical variation …
sources, including biological variation in cellular state as well as technical variation …
Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer's disease: review, recommendation, implementation and application
Alzheimer's disease (AD) is the most common form of dementia, characterized by
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …
Single-cell RNA sequencing with spatial transcriptomics of cancer tissues
Single-cell RNA sequencing (RNA-seq) techniques can perform analysis of transcriptome at
the single-cell level and possess an unprecedented potential for exploring signatures …
the single-cell level and possess an unprecedented potential for exploring signatures …
[HTML][HTML] Upcoming progress of transcriptomics studies on plants: An overview
P Tyagi, D Singh, S Mathur, A Singh… - Frontiers in Plant …, 2022 - frontiersin.org
Transcriptome sequencing or RNA-Sequencing is a high-resolution, sensitive and high-
throughput next-generation sequencing (NGS) approach used to study non-model plants …
throughput next-generation sequencing (NGS) approach used to study non-model plants …
[HTML][HTML] Unravelling glioblastoma heterogeneity by means of single-cell RNA sequencing
AH Martínez, R Madurga, N García-Romero… - Cancer letters, 2022 - Elsevier
Glioblastoma (GBM) is the most invasive and deadliest brain cancer in adults. Its inherent
heterogeneity has been designated as the main cause of treatment failure. Thus, a deeper …
heterogeneity has been designated as the main cause of treatment failure. Thus, a deeper …
Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals
Arteriogenesis rather than unspecialized capillary expansion is critical for restoring effective
circulation to compromised tissues in patients. Deciphering the origin and specification of …
circulation to compromised tissues in patients. Deciphering the origin and specification of …
Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models
K Song, X Yang, G An, X Xia, J Zhao, X Xu… - Nature …, 2022 - nature.com
Type 2 diabetes mellitus is one of the most prevalent metabolic diseases presenting with
systemic pathologies, including reproductive disorders in male diabetic patients. However …
systemic pathologies, including reproductive disorders in male diabetic patients. However …