Novel 1, 2, 4‐triazoles as antifungal agents

Z Kazeminejad, M Marzi, A Shiroudi… - BioMed Research …, 2022 - Wiley Online Library
The development of innovative antifungal agents is essential. Some fungicidal agents are no
longer effective due to resistance development, various side effects, and high toxicity …

Osteoarticular mycoses

MN Gamaletsou, B Rammaert, B Brause… - Clinical Microbiology …, 2022 - Am Soc Microbiol
Osteoarticular mycoses are chronic debilitating infections that require extended courses of
antifungal therapy and may warrant expert surgical intervention. As there has been no …

Efficacy of 12-months oral itraconazole versus 6-months oral itraconazole to prevent relapses of chronic pulmonary aspergillosis: an open-label, randomised …

IS Sehgal, S Dhooria, V Muthu, KT Prasad… - The Lancet Infectious …, 2022 - thelancet.com
Background Chronic pulmonary aspergillosis has a 5-year mortality of 50–80% globally, and
the optimal duration of treatment for chronic pulmonary aspergillosis remains unclear. We …

Pulmonary aspergillosis: diagnosis and treatment

F Lamoth, T Calandra - European Respiratory Review, 2022 - Eur Respiratory Soc
Aspergillus species are the most frequent cause of fungal infections of the lungs with a
broad spectrum of clinical presentations including invasive pulmonary aspergillosis (IPA) …

[HTML][HTML] Mucormycosis: risk factors, diagnosis, treatments, and challenges during COVID-19 pandemic

A Sharma, A Goel - Folia Microbiologica, 2022 - Springer
Mucormycosis is a deadly opportunistic disease caused by a group of fungus named
mucormycetes. Fungal spores are normally present in the environment and the immune …

[HTML][HTML] Emerging Fungal Infections: from the Fields to the Clinic, Resistant Aspergillus fumigatus and Dermatophyte Species: a One Health Perspective on an Urgent …

A Langfeldt, JAW Gold, T Chiller - Current Clinical Microbiology Reports, 2022 - Springer
Abstract Purpose of Review For this review, we use a One Health approach to examine two
globally emerging public health threats related to antifungal drug resistance: triazole …

A randomised trial of prednisolone versus prednisolone and itraconazole in acute-stage allergic bronchopulmonary aspergillosis complicating asthma

R Agarwal, V Muthu, IS Sehgal… - European …, 2022 - Eur Respiratory Soc
Background Whether a combination of glucocorticoid and antifungal triazole is superior to
glucocorticoid alone in reducing exacerbations in patients with allergic bronchopulmonary …

Antimicrobials and resistance part II: Antifungals, antivirals, and antiparasitics

FF Muhaj, SJ George, CD Nguyen, SK Tyring - Journal of the American …, 2022 - Elsevier
The available antifungal armamentarium consists of only a few drug classes, many limited in
their use by significant toxicities and dangerous drug interactions. Rising opportunistic …

Noninvasive testing and surrogate markers in invasive fungal diseases

GR Thompson III, DR Boulware, NC Bahr… - Open forum …, 2022 - academic.oup.com
Invasive fungal infections continue to increase as at-risk populations expand. The high
associated morbidity and mortality with fungal diseases mandate the continued investigation …

New perspectives on antimicrobial agents: isavuconazole

JS Lewis, NP Wiederhold, M Hakki… - Antimicrobial agents …, 2022 - Am Soc Microbiol
Isavuconazole is the newest of the clinically available advanced generation triazole
antifungals and is active against a variety of yeasts, molds, and dimorphic fungi. Its current …