Advances in maintenance immunosuppression over the past three decades have improved
solid organ transplantation outcomes dramatically. Uninterrupted access to …

Background Heart transplantation has become the standard of care for pediatric patients
with end‐stage heart disease, and outcomes have consistently improved over the last few …

Mechanistic target of rapamycin (mTOR) inhibitors are macrocyclic lactone antibiotics
derived from Streptomyces hygroscopicus that prevent T lymphocyte activation and B cell …

Background Survival after heart transplantation (HT) has improved considerably since the
first HT was performed in 1967 in Cape Town, South Africa. Understanding immunology …

Purpose We sought to evaluate the association between timing of cardiac allograft
vasculopathy (CAV) occurrence post-heart transplant (HT) with graft survival and …

The present research focuses on the development of ultrafine-grained commercial pure
titanium (cpTi)/sirolimus/polyethylene glycol (PEG)-coated substrate via a layer-by-layer …

Background Angiographic evidence of cardiac allograft vasculopathy (CAV angio) is a major
limiting factor to survival after heart transplantation (HTx). Prevention of CAV angio is …

Aims An artificial intelligence algorithm detecting age from 12-lead electrocardiogram (ECG)
has been suggested to reflect 'physiological age'. An increased physiological age has been …

Background Early detection of cardiac allograft rejection is crucial for post‐transplant graft
survival. Despite the progress made in immunosuppression strategies, acute cellular …

An alteration in extracellular matrix (ECM) production by vascular smooth muscle cells is a
crucial event in the pathogenesis of vascular diseases such as aging-related …