The VEGF/VEGFR axis revisited: implications for cancer therapy
P Mabeta, V Steenkamp - International journal of molecular sciences, 2022 - mdpi.com
The vascular endothelial growth factor (VEGF)/vascular endothelial growth factor receptor
(VEGFR) axis is indispensable in the process of angiogenesis and has been implicated as a …
(VEGFR) axis is indispensable in the process of angiogenesis and has been implicated as a …
Systems biology of angiogenesis signaling: Computational models and omics
Angiogenesis is a highly regulated multiscale process that involves a plethora of cells, their
cellular signal transduction, activation, proliferation, differentiation, as well as their …
cellular signal transduction, activation, proliferation, differentiation, as well as their …
VEGF-mediated augmentation of Autophagic and lysosomal activity in endothelial cells defends against intracellular Streptococcus pyogenes
ABSTRACT Group A Streptococcus (GAS), a deleterious human-pathogenic bacterium,
causes life-threatening diseases such as sepsis and necrotic fasciitis. We recently reported …
causes life-threatening diseases such as sepsis and necrotic fasciitis. We recently reported …
Current and novel therapeutic approaches for treatment of diabetic macular edema
MZ Chauhan, PA Rather, SM Samarah, AM Elhusseiny… - Cells, 2022 - mdpi.com
Diabetic macular edema (DME) is a major ocular complication of diabetes mellitus (DM),
leading to significant visual impairment. DME's pathogenesis is multifactorial. Focal edema …
leading to significant visual impairment. DME's pathogenesis is multifactorial. Focal edema …
Animal models of preeclampsia: mechanistic insights and promising therapeutics
EB Taylor, EM George - Endocrinology, 2022 - academic.oup.com
Preeclampsia (PE) is a common pregnancy-specific disorder that is a major cause of both
maternal and fetal morbidity and mortality. Central to the pathogenesis of PE is the …
maternal and fetal morbidity and mortality. Central to the pathogenesis of PE is the …
Endothelial dysfunction and thromboembolism in children, adolescents, and young adults with acute lymphoblastic leukemia
L Andrés-Jensen, K Grell, CU Rank, BK Albertsen… - Leukemia, 2022 - nature.com
Endothelial dysfunction has not previously been investigated as a thrombogenic risk factor
among patients with acute lymphoblastic leukemia (ALL), known to be at high risk of …
among patients with acute lymphoblastic leukemia (ALL), known to be at high risk of …
The Role of Alternative Splicing in Cancer: Regulatory Mechanism, Therapeutic Strategy, and Bioinformatics Application
YJ Pan, B Liu, DS Pei - DNA and Cell Biology, 2022 - liebertpub.com
Alternative splicing (AS) can generate distinct transcripts and subsequent isoforms that play
differential functions from the same pre-mRNA. Recently, increasing numbers of studies …
differential functions from the same pre-mRNA. Recently, increasing numbers of studies …
[HTML][HTML] 麝香通心滴丸通过促血管新生改善糖尿病合并心肌梗死大鼠心功能的作用机制研究
张梦笛, 崔鑫钰, 袁悦莹, 张雨婷, 于雪, 吴晏 - 天津中医药, 2022 - tjzhongyiyao.ijournals.cn
[目的] 从促进血管新生角度探究麝香通心滴丸对糖尿病合并心肌梗死大鼠心功能的保护效果和
作用机制.[方法] 通过腹腔注射链脲佐菌素(55 mg/kg) 及冠状动脉左前降支结扎术建立糖尿病 …
作用机制.[方法] 通过腹腔注射链脲佐菌素(55 mg/kg) 及冠状动脉左前降支结扎术建立糖尿病 …
The Role of the Microenvironment in Endometriosis: Parallels and Distinctions to Cancer
MS Rogers - Biomarkers of the Tumor Microenvironment, 2022 - Springer
Phenotypes viewed as distinctive to cancer are often recapitulated in benign disease and
consideration of these diseases can inform our understanding of the cancer …
consideration of these diseases can inform our understanding of the cancer …
Systems biology modeling of endothelial cell and macrophage signaling in angiogenesis in human diseases
Angiogenesis is an important biological process involved in development, growth,
reproduction, and wound healing. Dysregulation of angiogenesis is linked to many …
reproduction, and wound healing. Dysregulation of angiogenesis is linked to many …