Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?

SE Engelen, AJB Robinson, YX Zurke… - Nature Reviews …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …

Diagnosis and treatment of acute coronary syndromes: a review

DL Bhatt, RD Lopes, RA Harrington - Jama, 2022 - jamanetwork.com
Importance Acute coronary syndromes (ACS) are characterized by a sudden reduction in
blood supply to the heart and include ST-segment elevation myocardial infarction (STEMI) …

Targeting the microenvironment of vulnerable atherosclerotic plaques: an emerging diagnosis and therapy strategy for atherosclerosis

S Zhang, Y Liu, Y Cao, S Zhang, J Sun… - Advanced …, 2022 - Wiley Online Library
Atherosclerosis is considered one of the primary causes of cardiovascular diseases (CVDs).
Unpredictable rupture of the vulnerable atherosclerotic plaques triggers adverse …

[HTML][HTML] Autophagy, pyroptosis, and ferroptosis: new regulatory mechanisms for atherosclerosis

L Lin, MX Zhang, L Zhang, D Zhang, C Li… - Frontiers in cell and …, 2022 - frontiersin.org
Atherosclerosis is a chronic inflammatory disorder characterized by the gradual buildup of
plaques within the vessel wall of middle-sized and large arteries. The occurrence and …

Bionanoparticles in cancer imaging, diagnosis, and treatment

Y Li, Q Bao, S Yang, M Yang, C Mao - View, 2022 - Wiley Online Library
Biological molecules such as DNA, proteins, and lipids can be assembled into naturally
existing nanoparticles, such as bacterial viruses (also called bacteriophages or phages) …

Animal models of atherosclerosis–supportive notes and tricks of the trade

A Gisterå, DFJ Ketelhuth, SG Malin… - Circulation …, 2022 - Am Heart Assoc
Atherosclerotic cardiovascular disease is a major cause of death among humans. Animal
models have shown that cholesterol and inflammation are causatively involved in the …

[HTML][HTML] There is urgent need to treat atherosclerotic cardiovascular disease risk earlier, more intensively, and with greater precision: A review of current practice and …

ME Makover, MD Shapiro, PP Toth - American Journal of Preventive …, 2022 - Elsevier
Atherosclerotic cardiovascular disease (ASCVD) is epidemic throughout the world and is
etiologic for such acute cardiovascular events as myocardial infarction, ischemic stroke …

Deep learning artificial intelligence framework for multiclass coronary artery disease prediction using combination of conventional risk factors, carotid ultrasound, and …

AM Johri, KV Singh, LE Mantella, L Saba… - Computers in Biology …, 2022 - Elsevier
Objective Cardiovascular disease (CVD) is a major healthcare challenge and therefore early
risk assessment is vital. Previous assessment techniques use either “conventional CVD risk …

3D‐Printed Micro Lens‐in‐Lens for In Vivo Multimodal Microendoscopy

J Li, S Thiele, RW Kirk, BC Quirk, A Hoogendoorn… - Small, 2022 - Wiley Online Library
Multimodal microendoscopes enable co‐located structural and molecular measurements in
vivo, thus providing useful insights into the pathological changes associated with disease …

Interferon regulatory factor-5-dependent CD11c+ macrophages contribute to the formation of rupture–prone atherosclerotic plaques

A Edsfeldt, M Swart, P Singh, L Dib, J Sun… - European heart …, 2022 - academic.oup.com
Aims Inflammation is a key factor in atherosclerosis. The transcription factor interferon
regulatory factor-5 (IRF5) drives macrophages towards a pro-inflammatory state. We …