Epigenetic changes associated with histone modifications play an important role in the
emergence and maintenance of the phenotype of various cancer types. In contrast to direct …

Epigentic enzymes histone deacetylases (HDACs) catalyze the removal of acetyl groups
from the ε-N-acetylated lysine residues of various protein substrates including both histone …

The deacetylation process regulated by histone deacetylases (HDACs) plays an important
role in human health and diseases. HDAC6 belongs to the Class IIb of HDACs family, which …

Dysregulation of the epigenetic enzyme-mediated transcription of oncogenes or tumor
suppressor genes is closely associated with the occurrence, progression, and prognosis of …

Heterocycles are being playing an important role in cancer treatment for years. Currently, a
number of anticancer agents are available on market, but concerns such as less …

Alkenes represent one of the most useful building blocks for organic synthesis, owing to their
abundance and versatile reactivity. Transition metal (Pd, Cu, Co, Ni, Fe, etc.) catalyzed …

Non-selective inhibition of different histone deacetylase enzymes by hydroxamic acid-based
drugs causes severe side effects when used as a (long-term) cancer treatment. In this work …

The design of multi-target drugs acting simultaneously on multiple signaling pathways is a
growing field in medicinal chemistry, especially for the treatment of complex diseases, such …

A series of novel N-alkyl-N-hydroxyl carboximates derived from β-elemene were fortuitously
discovered. Most of them showed more potent anti-proliferative activities than their lead …

Inhibition of histone deacetylase 6 (HDAC6) in the brain is a highly attractive therapeutic
target for the treatment of neurodegenerative diseases. The low blood–brain barrier …