miRNA-486-5p: signaling targets and role in non-malignant disease

A Douvris, J Viñas, KD Burns - Cellular and Molecular Life Sciences, 2022 - Springer
MicroRNAs (miRNAs) are short non-coding RNAs, highly conserved between species, that
are powerful regulators of gene expression. Aberrant expression of miRNAs alters biological …

HMGB1-mediated activation of the inflammatory-reparative response following myocardial infarction

E Foglio, L Pellegrini, MA Russo, F Limana - Cells, 2022 - mdpi.com
Different cell types belonging to the innate and adaptive immune system play mutually non-
exclusive roles during the different phases of the inflammatory-reparative response that …

Combined approach to eptifibatide and thrombectomy in acute ischemic stroke because of large vessel occlusion: a matched-control analysis

G Ma, X Sun, H Cheng, WS Burgin, W Luo, W Jia, Y Liu… - Stroke, 2022 - Am Heart Assoc
Background: In patients undergoing mechanical thrombectomy (MT), adjunctive
antithrombotic might improve angiographic reperfusion, reduce the risk of distal emboli and …

Increasing myocardial edema is associated with greater microvascular obstruction in ST-segment elevation myocardial infarction

NL Bonfig, CR Soukup, AA Shah… - American Journal …, 2022 - journals.physiology.org
Microvascular obstruction (MVO) frequently develops after ST-elevation myocardial
infarction (STEMI) and is associated with increased mortality and adverse left ventricular …

Mammalian target of rapamycin inhibition in patients with ST-segment elevation myocardial infarction

BE Stähli, R Klingenberg, D Heg, M Branca… - Journal of the American …, 2022 - jacc.org
Background Early inflammation following acute ST-segment elevation myocardial infarction
(STEMI) treated by primary percutaneous coronary intervention (PCI) affects myocardial …

[HTML][HTML] Implication of IGF1R signaling in the protective effect of Astragaloside IV on ischemia and reperfusion-induced cardiac microvascular endothelial …

K He, L Yan, SQ Lin, YY Liu, BH Hu, X Chang, XR Zhao… - Phytomedicine, 2022 - Elsevier
Background Myocardial ischemia-reperfusion (I/R) causes damage to coronary capillary
endothelial barrier and microvascular leakage (MVL), aggravating tissue injury and heart …

Controlled-Level EVERolimus in Acute Coronary Syndrome (CLEVER-ACS)-A phase II, randomized, double-blind, multi-center, placebo-controlled trial

R Klingenberg, BE Stähli, D Heg, A Denegri… - American Heart …, 2022 - Elsevier
Background Activation of inflammatory pathways during acute myocardial infarction
contributes to infarct size and left ventricular (LV) remodeling. The present prospective …

Post–ST‐segment–elevation myocardial infarction platelet reactivity is associated with the extent of microvascular obstruction and infarct size as determined by …

E Massalha, D Oren, O Goitein, Y Brodov… - Journal of the …, 2022 - Am Heart Assoc
Background Despite optimized medical management and techniques of primary
percutaneous coronary intervention, a substantial proportion of patients with ST‐segment …

[HTML][HTML] Lipid nitroalkene nanoparticles for the focal treatment of ischemia reperfusion

ZY Gary, T Ramasamy, M Fazzari, X Chen… - …, 2022 - ncbi.nlm.nih.gov
Rationale: The treatment of microvascular obstruction (MVO) using ultrasound-targeted LNP
cavitation (UTC) therapy mechanically relieves the physical obstruction in the …

[HTML][HTML] Impact of the total ischemia time on No-reflow phenomenon in patients with ST elevation myocardial infarction undergoing primary percutaneous coronary …

M Khalfallah, A Allaithy, DA Maria - Anatolian journal of cardiology, 2022 - ncbi.nlm.nih.gov
Background No-reflow phenomenon after primary percutaneous coronary intervention is a
common condition affecting the outcomes; therefore, studying its predictive factors is helpful …