Noncommunicable diseases are chronic diseases that contribute to death worldwide, but
these diseases can be prevented and mitigated with regular exercise. Exercise activates …

Transcriptional regulation of catabolic pathways is a central mechanism by which cells
respond to physiological cues to generate the energy required for anabolic pathways …

In the 1950s, the production of processed fats and oils from coconut oil was popular in the
United States. It became necessary to find uses for the medium-chain fatty acids (MCFAs) …

Insulin resistance, a harbinger of the metabolic syndrome, is a state of compromised
hormonal response resulting from the dysregulation of a wide range of insulin-controlled …

Disturbances in lipid homeostasis can cause mitochondrial dysfunction and lipotoxicity.
Perilipin 5 (PLIN5) decorates intracellular lipid droplets (LDs) in oxidative tissues and …

Dietary intervention is widely used as a therapeutic approach ranging from the treatment of
neurological disorders to attempts to extend lifespan. The most important effect of various …

Recent studies have suggested that irisin may act as a potential neurokine. Exercise and L-
carnosine supplementation showed neuroprotective effects in Alzheimer's disease (AD)–like …

Doxorubicin (Dox) is the standard treatment approach for osteosarcoma (OS), while
acquired drug resistance seriously attenuates its treatment efficiency. The present study …

Regulation of the pyruvate dehydrogenase (PDH) complex by the pyruvate dehydrogenase
kinase PDK4 enables the heart to respond to fluctuations in energy demands and substrate …

Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent forms of chronic liver
diseases and is causally linked to hepatic insulin resistance and reduced fatty acid …