[HTML][HTML] PROTACs technology for treatment of Alzheimer's disease: Advances and perspectives
Neurodegenerative diseases (NDs) are characteristic with progression of neuron
degeneration, resulting in dysfunction of cognition and mobility. Many neurodegenerative …
degeneration, resulting in dysfunction of cognition and mobility. Many neurodegenerative …
Sex differences in training-induced activity of the ubiquitin proteasome system in the dorsal hippocampus and medial prefrontal cortex of male and female mice
SB Beamish, KS Gross, MKM Anderson… - Learning & …, 2022 - learnmem.cshlp.org
The ubiquitin proteasome system (UPS) is a primary mechanism through which proteins are
degraded in cells. UPS activity in the dorsal hippocampus (DH) is necessary for multiple …
degraded in cells. UPS activity in the dorsal hippocampus (DH) is necessary for multiple …
A putative role for ubiquitin-proteasome signaling in estrogenic memory regulation
SB Beamish, KM Frick - Frontiers in behavioral neuroscience, 2022 - frontiersin.org
Sex steroid hormones such as 17β-estradiol (E2) are critical neuromodulators of
hippocampal synaptic plasticity and hippocampus-dependent memory in both males and …
hippocampal synaptic plasticity and hippocampus-dependent memory in both males and …
Effects of sex and retention interval on the retrieval and extinction of auditory fear conditioning
HL Schoenberg, M Blanchard, HY Cheng… - Frontiers in behavioral …, 2022 - frontiersin.org
Fear memory retrieval is relevant to psychiatric disorders such as post-traumatic stress
disorder (PTSD). One of the hallmark symptoms of PTSD is the repeated retrieval and re …
disorder (PTSD). One of the hallmark symptoms of PTSD is the repeated retrieval and re …
The epigenetic role of proteasome subunit RPT6 during memory formation in female rats
K Farrell, A Auerbach, M Musaus… - Learning & …, 2022 - learnmem.cshlp.org
Reports of sex differences in the neurobiology of memory formation are becoming more
prevalent. Despite this, much remains unknown about the role of sex in this process. We …
prevalent. Despite this, much remains unknown about the role of sex in this process. We …
Protein SUMOylation is a sex-specific regulator of fear memory formation in the amygdala
A Gustin, S Navabpour, K Farrell, K Martin… - Behavioural brain …, 2022 - Elsevier
Strong evidence has implicated ubiquitin signaling in the process of fear memory formation.
While less abundant than ubiquitination, evidence suggests that protein SUMOylation may …
While less abundant than ubiquitination, evidence suggests that protein SUMOylation may …