Atopic dermatitis: an expanding therapeutic pipeline for a complex disease

T Bieber - Nature reviews Drug discovery, 2022 - nature.com
Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a complex
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …

Multiple roles for cytokines in atopic dermatitis: from pathogenic mediators to endotype-specific biomarkers to therapeutic targets

L Fania, G Moretta, F Antonelli, E Scala… - International Journal of …, 2022 - mdpi.com
Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases, which
generally presents with intense itching and recurrent eczematous lesions. AD affects up to …

Skin care interventions in infants for preventing eczema and food allergy

MM Kelleher, R Phillips, SJ Brown… - Cochrane Database …, 2022 - cochranelibrary.com
Background Eczema and food allergy are common health conditions that usually begin in
early childhood and often occur in the same people. They can be associated with an …

Nemolizumab plus topical agents in patients with atopic dermatitis (AD) and moderate‐to‐severe pruritus provide improvement in pruritus and signs of AD for up to 68 …

K Kabashima, T Matsumura, H Komazaki… - British Journal of …, 2022 - academic.oup.com
Summary Background Interleukin (IL)‐31 affects the inflammatory response, is involved in
epidermal barrier disruption in atopic dermatitis (AD) and plays a key role in pruritus …

Efficacy and safety of baricitinib in combination with topical corticosteroids in patients with moderate‐to‐severe atopic dermatitis with inadequate response, intolerance …

T Bieber, K Reich, C Paul, Y Tsunemi… - British Journal of …, 2022 - academic.oup.com
Background Baricitinib, an oral selective Janus kinase (JAK) 1 and JAK 2 inhibitor, was
shown to improve the signs and symptoms of moderate‐to‐severe atopic dermatitis (AD) …

Current and emerging strategies to inhibit type 2 inflammation in atopic dermatitis

EB Haddad, SL Cyr, K Arima, RA McDonald… - Dermatology and …, 2022 - Springer
Type 2 immunity evolved to combat helminth infections by orchestrating a combined
protective response of innate and adaptive immune cells and promotion of parasitic worm …

Bleach baths for atopic dermatitis: A systematic review and meta-analysis including unpublished data, Bayesian interpretation, and GRADE

L Bakaa, JM Pernica, RJ Couban, KJ Tackett… - Annals of Allergy …, 2022 - Elsevier
Background Bleach bathing is frequently recommended to treat atopic dermatitis (AD), but its
efficacy and safety are uncertain. Objective To systematically synthesize randomized …

The family impact of atopic dermatitis in the pediatric population: results from an international cross-sectional study

S Barbarot, JI Silverberg, A Gadkari, EL Simpson… - The Journal of …, 2022 - Elsevier
Objective To evaluate the impact of atopic dermatitis on families of pediatric patients. Study
design This cross-sectional, web-based survey of children/adolescents (6 months to< 18 …

Effectiveness and safety of upadacitinib in the treatment of moderate-severe atopic dermatitis: a multicentric, prospective, real-world, cohort study

A Chiricozzi, N Gori, A Narcisi, A Balato… - Drugs in R&D, 2022 - Springer
Background The efficacy and safety of upadacitinib in atopic dermatitis (AD) have been
defined in clinical trials, but no real-world data are currently available. We aimed to assess …

Moderate‐to‐severe atopic dermatitis in adolescents treated with dupilumab: a multicentre Italian real‐world experience

L Stingeni, L Bianchi, E Antonelli… - Journal of the …, 2022 - Wiley Online Library
Background Moderate‐to‐severe atopic dermatitis (AD) in the adolescence is a high burden
disease, and its treatment can be very challenging due to paucity of approved systemic …