Atopic dermatitis: an expanding therapeutic pipeline for a complex disease
T Bieber - Nature reviews Drug discovery, 2022 - nature.com
Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a complex
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …
Multiple roles for cytokines in atopic dermatitis: from pathogenic mediators to endotype-specific biomarkers to therapeutic targets
Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases, which
generally presents with intense itching and recurrent eczematous lesions. AD affects up to …
generally presents with intense itching and recurrent eczematous lesions. AD affects up to …
Skin care interventions in infants for preventing eczema and food allergy
MM Kelleher, R Phillips, SJ Brown… - Cochrane Database …, 2022 - cochranelibrary.com
Background Eczema and food allergy are common health conditions that usually begin in
early childhood and often occur in the same people. They can be associated with an …
early childhood and often occur in the same people. They can be associated with an …
Nemolizumab plus topical agents in patients with atopic dermatitis (AD) and moderate‐to‐severe pruritus provide improvement in pruritus and signs of AD for up to 68 …
K Kabashima, T Matsumura, H Komazaki… - British Journal of …, 2022 - academic.oup.com
Summary Background Interleukin (IL)‐31 affects the inflammatory response, is involved in
epidermal barrier disruption in atopic dermatitis (AD) and plays a key role in pruritus …
epidermal barrier disruption in atopic dermatitis (AD) and plays a key role in pruritus …
Efficacy and safety of baricitinib in combination with topical corticosteroids in patients with moderate‐to‐severe atopic dermatitis with inadequate response, intolerance …
T Bieber, K Reich, C Paul, Y Tsunemi… - British Journal of …, 2022 - academic.oup.com
Background Baricitinib, an oral selective Janus kinase (JAK) 1 and JAK 2 inhibitor, was
shown to improve the signs and symptoms of moderate‐to‐severe atopic dermatitis (AD) …
shown to improve the signs and symptoms of moderate‐to‐severe atopic dermatitis (AD) …
Current and emerging strategies to inhibit type 2 inflammation in atopic dermatitis
EB Haddad, SL Cyr, K Arima, RA McDonald… - Dermatology and …, 2022 - Springer
Type 2 immunity evolved to combat helminth infections by orchestrating a combined
protective response of innate and adaptive immune cells and promotion of parasitic worm …
protective response of innate and adaptive immune cells and promotion of parasitic worm …
Bleach baths for atopic dermatitis: A systematic review and meta-analysis including unpublished data, Bayesian interpretation, and GRADE
Background Bleach bathing is frequently recommended to treat atopic dermatitis (AD), but its
efficacy and safety are uncertain. Objective To systematically synthesize randomized …
efficacy and safety are uncertain. Objective To systematically synthesize randomized …
The family impact of atopic dermatitis in the pediatric population: results from an international cross-sectional study
S Barbarot, JI Silverberg, A Gadkari, EL Simpson… - The Journal of …, 2022 - Elsevier
Objective To evaluate the impact of atopic dermatitis on families of pediatric patients. Study
design This cross-sectional, web-based survey of children/adolescents (6 months to< 18 …
design This cross-sectional, web-based survey of children/adolescents (6 months to< 18 …
Effectiveness and safety of upadacitinib in the treatment of moderate-severe atopic dermatitis: a multicentric, prospective, real-world, cohort study
A Chiricozzi, N Gori, A Narcisi, A Balato… - Drugs in R&D, 2022 - Springer
Background The efficacy and safety of upadacitinib in atopic dermatitis (AD) have been
defined in clinical trials, but no real-world data are currently available. We aimed to assess …
defined in clinical trials, but no real-world data are currently available. We aimed to assess …
Moderate‐to‐severe atopic dermatitis in adolescents treated with dupilumab: a multicentre Italian real‐world experience
L Stingeni, L Bianchi, E Antonelli… - Journal of the …, 2022 - Wiley Online Library
Background Moderate‐to‐severe atopic dermatitis (AD) in the adolescence is a high burden
disease, and its treatment can be very challenging due to paucity of approved systemic …
disease, and its treatment can be very challenging due to paucity of approved systemic …