Distinct epigenetic modifiers ensure coordinated control over genes that govern a myriad of
cellular processes. Growing evidence shows that dynamic regulation of histone methylation …

Simple Summary Aberrations in epigenetic modulators have been widely identified in
cancer; therefore, these modulators are attractive targets for cancer treatment. KDM5 is an …

The widespread availability of genetic testing for those with neurodevelopmental disorders
has highlighted the importance of many genes necessary for the proper development and …

Acute myeloid leukemias (AMLs) with the NUP98-NSD1 or mixed lineage leukemia (MLL)
rearrangement (MLL-r) share transcriptomic profiles associated with stemness-related gene …

Mammalian histone demethylases of the KDM5 family are mediators of gene expression
dynamics during developmental, cellular differentiation, and other nuclear processes. They …

Lysine specific demethylase 1 (LSD1) regulates gene expression as part of the CoREST
complex, along with co-repressor of REST (CoREST) and histone deacetylase 1 (HDAC1) …

Chronic hepatitis B (CHB) is a global health care challenge and a major cause of liver
disease. To find new therapeutic avenues with a potential to functionally cure chronic …

Histone modifying enzymes are involved in the posttranslational modification of histones
and the epigenetic control of gene expression. They play a critical role in normal …

The United States is undergoing a demographic shift towards an older population with
profound economic, social, and healthcare implications. The number of Americans aged 65 …

Abstract The H3K4 demethylase KDM5B is overexpressed in multiple cancer types, and
elevated expression levels of KDM5B is associated with decreased survival. However, the …