Boveri and beyond: Chromothripsis and genomic instability from mitotic errors
Mitotic cell division is tightly monitored by checkpoints that safeguard the genome from
instability. Failures in accurate chromosome segregation during mitosis can cause …
instability. Failures in accurate chromosome segregation during mitosis can cause …
[HTML][HTML] Compromised mitotic fidelity in human pluripotent stem cells
I Milagre, C Pereira, RA Oliveira - International Journal of Molecular …, 2023 - mdpi.com
Human pluripotent stem cells (PSCs), which include both embryonic and induced pluripotent
stem cells, are widely used in fundamental and applied biomedical research. They have …
stem cells, are widely used in fundamental and applied biomedical research. They have …
[HTML][HTML] MCAK inhibitors induce aneuploidy in triple-negative breast cancer models
JC Smith, S Husted, J Pilrose, SC Ems-McClung… - Cancers, 2023 - mdpi.com
Simple Summary Triple-negative breast cancer (TNBC) is the most lethal breast cancer
subtype with few treatment options available. Standard of care for TNBC involves the use of …
subtype with few treatment options available. Standard of care for TNBC involves the use of …
Adaptation to high rates of chromosomal instability and aneuploidy through multiple pathways in budding yeast
MN Clarke, T Marsoner, MAY Adell… - The EMBO …, 2023 - embopress.org
Both an increased frequency of chromosome missegregation (chromosomal instability, CIN)
and the presence of an abnormal complement of chromosomes (aneuploidy) are hallmarks …
and the presence of an abnormal complement of chromosomes (aneuploidy) are hallmarks …
Oxidative stress induces chromosomal instability through replication stress in fibroblasts from aged mice
Chromosomal aneuploidy has been associated with aging. However, whether and how
chromosomal instability (CIN), a condition frequently seen in cancer cells in which …
chromosomal instability (CIN), a condition frequently seen in cancer cells in which …
Twenty years of merotelic kinetochore attachments: a historical perspective
D Cimini - Chromosome Research, 2023 - Springer
Micronuclei, small DNA-containing structures separate from the main nucleus, were used for
decades as an indicator of genotoxic damage. Micronuclei containing whole chromosomes …
decades as an indicator of genotoxic damage. Micronuclei containing whole chromosomes …
[PDF][PDF] A pluripotent developmental state confers a low fidelity of chromosome segregation
C Deng, A Ya, DA Compton, KM Godek - Stem Cell Reports, 2023 - cell.com
During in vitro propagation, human pluripotent stem cells (hPSCs) frequently become
aneuploid with incorrect chromosome numbers due to mitotic chromosome segregation …
aneuploid with incorrect chromosome numbers due to mitotic chromosome segregation …
Dual mechanism of kinetochore microtubule detachment
During eukaryotic cell division, microtubules connect to chromosomes by attaching to the
kinetochore via the NDC80 complex (NDC80c). The regulation of kinetochore microtubule …
kinetochore via the NDC80 complex (NDC80c). The regulation of kinetochore microtubule …
4-PYRROLIDIN-1-Yl-5-P-TOLYL-THIENO [2, 3-D] PYRIMIDINE FOR USE IN THE TREATMENT OF AGING-ASSOCIATED AND PREMATURE AGING DISEASES …
ECCL SANTOS - US Patent App. 17/800,723, 2023 - Google Patents
US20230346785A1 - 4-PYRROLIDIN-1-Yl-5-P-TOLYL-THIENO[2,3-D] PYRIMIDINE FOR
USE IN THE TREATMENT OF AGING-ASSOCIATED AND PREMATURE AGING DISEASES …
USE IN THE TREATMENT OF AGING-ASSOCIATED AND PREMATURE AGING DISEASES …
Targeting chromosomal instability and downstream cytosolic DNA signaling for cancer treatment
2020-11-17 Assigned to CORNELL UNIVERSITY reassignment CORNELL UNIVERSITY
CORRECTIVE ASSIGNMENT TO CORRECT THE CORRECT INVENTORSHIP FROM …
CORRECTIVE ASSIGNMENT TO CORRECT THE CORRECT INVENTORSHIP FROM …