Medicinal plant molecules against hepatitis C virus: Current status and future prospect
A Mandal, B Hazra - Phytotherapy Research, 2023 - Wiley Online Library
Hepatitis C virus (HCV), a global malady, causes acute and chronic hepatitis leading to
permanent liver damage, hepatocellular carcinoma, and death. Modern anti‐HCV therapies …
permanent liver damage, hepatocellular carcinoma, and death. Modern anti‐HCV therapies …
Lessons learnt from COVID-19: computational strategies for facing present and future pandemics
Since its outbreak in December 2019, the COVID-19 pandemic has caused the death of
more than 6.5 million people around the world. The high transmissibility of its causative …
more than 6.5 million people around the world. The high transmissibility of its causative …
Catalytic Olefin Cyclopropanation with In Situ-Generated Dialkyl Diazomethanes via Co (II)-Based Metalloradical Catalysis
The synthesis of dialkyl-substituted cyclopropanes is an important challenge in synthesis
with applications in drug discovery and agrochemistry. Herein, we report on the synthesis of …
with applications in drug discovery and agrochemistry. Herein, we report on the synthesis of …
Direct-acting antiviral resistance of Hepatitis C virus is promoted by epistasis
H Zhang, AA Quadeer, MR McKay - Nature Communications, 2023 - nature.com
Direct-acting antiviral agents (DAAs) provide efficacious therapeutic treatments for chronic
Hepatitis C virus (HCV) infection. However, emergence of drug resistance mutations (DRMs) …
Hepatitis C virus (HCV) infection. However, emergence of drug resistance mutations (DRMs) …
[HTML][HTML] Hepatitis C Virus: Insights Into Its History, Treatment, Challenges, and Future Directions
LA Bernal, V Soti - Cureus, 2023 - ncbi.nlm.nih.gov
Hepatitis C virus (HCV) is a global public health concern with significant impacts. It primarily
spreads through blood-to-blood contact, such as sharing needles among drug users. Given …
spreads through blood-to-blood contact, such as sharing needles among drug users. Given …
Programmable Proteolysis-Activated Transcription for Highly Sensitive Ratiometric Electrochemical Detection of Viral Protease
S Xie, C Zhu, L Yang, H Li, H Zhu, Z Nie… - Analytical …, 2023 - ACS Publications
Viral proteases play a crucial role in viral infection and are regarded as promising targets for
antiviral drug development. Consequently, biosensing methods that target viral proteases …
antiviral drug development. Consequently, biosensing methods that target viral proteases …
Exploring the synthetic approaches and clinical prowess of established macrocyclic pharmaceuticals
JG Sun, P Nie, P Herdewijn, XJ Li - European Journal of Medicinal …, 2023 - Elsevier
Macrocyclic compounds, characterized by cyclic structures, often originate from either
modified forms of unicyclic canonical molecules or natural products. Within the field of …
modified forms of unicyclic canonical molecules or natural products. Within the field of …
Palladium-catalyzed intramolecular asymmetric hydrocyclopropanylation of alkynes: synthesis of cyclopropane-fused γ-lactams
HZ Lin, Z Qi, QM Wu, YY Jiang, JB Peng - Chemical Science, 2023 - pubs.rsc.org
A palladium-catalyzed intramolecular asymmetric hydrocyclopropanylation of alkynes via C
(sp3)–H activation has been developed for the synthesis of cyclopropane-fused γ-lactams …
(sp3)–H activation has been developed for the synthesis of cyclopropane-fused γ-lactams …
[HTML][HTML] Oncoviruses: how do they hijack their host and current treatment regimes
Viruses have the ability to modulate the cellular machinery of their host to ensure their
survival. While humans encounter numerous viruses daily, only a select few can lead to …
survival. While humans encounter numerous viruses daily, only a select few can lead to …
Hepatitis C and Nonalcoholic Steatohepatitis in the 21st Century: Impact on Liver Disease and Liver Transplantation
S Samuel, A Abulawi, R Malik - Gastroenterology Insights, 2023 - mdpi.com
Hepatitis C infection is a leading etiology of hepatic dysfunction and a major indication for
liver transplantation due to the development of fibrosis, cirrhosis, and hepatocellular …
liver transplantation due to the development of fibrosis, cirrhosis, and hepatocellular …