Recently, the immune system has been identified as one of the possible main bridges which
connect the gut–brain axis. This review aims to examine available evidence on the …

Women experience chronic pain more often than men with some pain conditions being
specific to women while others are more prevalent in women. Prolactin, a neuropeptide …

Pain continues to be an enormous global health challenge, with millions of new untreated or
inadequately treated patients reported annually. With respect to current clinical applications …

Polystichum lonchitis L. is a fern belonging to the family Dryopteridaceae. The present study
was conducted to evaluate its pharmacological, antioxidant, and phytochemical properties …

A new generation of dual-target μ opioid receptor (MOR) agonist/dopamine D3 receptor
(D3R) antagonist/partial agonists with optimized physicochemical properties was designed …

Opioid receptor agonists, particularly those that activate µ-opioid receptors (MORs), are
essential analgesic agents for acute or chronic mild to severe pain treatment. However, their …

Endometriosis (EM), defined as the presence of endometrial-like tissue with surrounding
smooth muscle cells outside the uterus, is a disregarded gynecological disease reported to …

Definido como la sensación desagradable que provoca el deseo de rascarse, el prurito es
el síntoma cutáneo más frecuente asociado a la uremia, pudiendo aparecer en casi la mitad …

Objective: To review data for difelikefalin (Korsuva) intravenous solution for management of
moderate-to-severe pruritus in hemodialysis (HD) patients. Data Sources: Literature search …

Objective The present study evaluated the antinociceptive activity of Calendula officinalis
L.(Ca) cream on inflammatory hypernociception. Methods Creams with different Ca …