Disease overview Acute myeloid leukemia (AML) is a frequently fatal bone marrow stem cell
cancer characterized by unbridled proliferation of malignant marrow stem cells with …

The treatment of acute myeloid leukemia (AML) has evolved over the past few years with the
advent of next-generation sequencing. Targeted therapies alone or in combination with low …

Simple Summary The development of BCL-2 inhibitors as a pivotal approach in cancer
treatment lies in their ability to effectively trigger apoptosis in tumor cells. Venetoclax, a …

In recent years, the therapeutic landscape of myeloid malignancies has been completely
revolutionized by the introduction of several new drugs, targeting molecular alterations or …

The cellular pathway of apoptosis is tightly regulated by a balance between pro-apoptotic
and anti-apoptotic proteins [1]. One of the major regulators of the intrinsic pathway is the B …

Myelodysplastic syndromes (MDSs) belong to a group of clonal bone marrow malignancies.
In light of the emergence of new molecules, a significant contribution to the understanding of …

The long-term outcome of allogeneic hematopoietic stem cell transplantation (HSCT) in
chemorefractory acute myeloid leukemia (AML) remains suboptimal because of a high …

Background Venetoclax monotherapy is an effective option for patients with acute myeloid
leukemia (AML). Venetoclax has also been used in non-myeloablative conditioning …

This prospective clinical investigation focused on the addition of venetoclax and decitabine
to myeloablative conditioning regimens, targeting high-risk and elderly individuals …

急性髓系白血病(AML) 是成人中最常见的急性白血病类型, 严重危害人类健康.
异基因造血干细胞移植(allo HsCT) 是治疗AML 的主要手段. 白血病复发是AML …