Acinetobacter baumannii is recognized as a clinically significant pathogen causing a wide
spectrum of nosocomial infections. Colistin was considered a last-resort antibiotic for the …

Acinetobacter baumannii is a Gram-negative coccobacillus with exceptional survival skills in
an unfavorable environment and the ability to rapidly acquire antibiotic resistance, making it …

Summary Background Carbapenem-resistant Acinetobacter baumannii (CRAB) is a major
public health concern globally. Often studied in the context of hospital outbreaks, little is …

Identifying protein thermodynamic stability changes upon single-point variants is crucial for
studying mutation-induced alterations in protein biophysics, genomic variants, and mutation …

Despite colossal achievements in antibiotic therapy in recent decades, drug-resistant
pathogens have remained a leading cause of death and economic loss globally. One such …

Abstract Background The prevalence of Acinetobacter baumannii in nosocomial infections
and its remarkable ability to develop antimicrobial resistance have been a critical issue in …

Motivation Quantitative determination of protein thermodynamic stability is a critical step in
protein and drug design. Reliable prediction of protein stability changes caused by point …

Introduction Although carbapenemases are frequently reported in resistant A. baumannii
clinical isolates, other chromosomally mediated elements of resistance that are considered …

The development and approval of antivirals against SARS-CoV-2 has further equipped
clinicians with treatment strategies against the COVID-19 pandemic, reducing deaths post …

The aminoglycoside antibiotics amikacin, gentamicin, and tobramycin are important
therapeutic options for Acinetobacter iinfections. Several genes that confer resistance to one …