Developing phage therapy that overcomes the evolution of bacterial resistance

A Oromí-Bosch, JD Antani… - Annual Review of Virology, 2023 - annualreviews.org
The global rise of antibiotic resistance in bacterial pathogens and the waning efficacy of
antibiotics urge consideration of alternative antimicrobial strategies. Phage therapy is a …

Emergent crisis of antibiotic resistance: A silent pandemic threat to 21st century

F Akram, M Imtiaz, I ul Haq - Microbial Pathogenesis, 2023 - Elsevier
Antibiotic resistance has become an indispensably alarming menace to the global
community. The primary factors are overuse and abuse of antibiotics, lack of novel …

[HTML][HTML] Antimicrobial resistance and recent alternatives to antibiotics for the control of bacterial pathogens with an emphasis on foodborne pathogens

YA Helmy, K Taha-Abdelaziz, HAEH Hawwas, S Ghosh… - Antibiotics, 2023 - mdpi.com
Antimicrobial resistance (AMR) is one of the most important global public health problems.
The imprudent use of antibiotics in humans and animals has resulted in the emergence of …

[HTML][HTML] The future of clinical phage therapy in the United Kingdom

JD Jones, C Trippett, M Suleman, MRJ Clokie, JR Clark - Viruses, 2023 - mdpi.com
Bacteriophage (phage) therapy is a promising alternative antimicrobial strategy with the
potential to transform the way bacterial infections are treated. In the United Kingdom, phages …

[HTML][HTML] L-form conversion in Gram-positive bacteria enables escape from phage infection

JC Wohlfarth, M Feldmüller, A Schneller, S Kilcher… - Nature …, 2023 - nature.com
At the end of a lytic bacteriophage replication cycle in Gram-positive bacteria, peptidoglycan-
degrading endolysins that cause explosive cell lysis of the host can also attack non-infected …

[HTML][HTML] A century of clinical use of phages: a literature review

K Diallo, A Dublanchet - Antibiotics, 2023 - mdpi.com
Growing antibiotic resistance and the broken antibiotic market have renewed interest in the
use of phages, a century-old therapy that fell into oblivion in the West after two decades of …

[HTML][HTML] Immunogenicity of CRISPR therapeutics—Critical considerations for clinical translation

R Ewaisha, KS Anderson - Frontiers in Bioengineering and …, 2023 - frontiersin.org
CRISPR offers new hope for many patients and promises to transform the way we think of
future therapies. Ensuring safety of CRISPR therapeutics is a top priority for clinical …

The current status of phage therapy and its advancement towards establishing standard antimicrobials for combating multi drug-resistant bacterial pathogens

Y Ali, I Inusa, G Sanghvi, VB Mandaliya… - Microbial Pathogenesis, 2023 - Elsevier
Phage therapy; a revived antimicrobial weapon, has great therapeutic advantages with the
main ones being its ability to eradicate multidrug-resistant pathogens as well as selective …

Phage therapy in the management of urinary tract infections: a comprehensive systematic review

AM Al-Anany, PB Hooey, JD Cook, LL Burrows… - Phage, 2023 - liebertpub.com
Urinary tract infections (UTIs) are a problem worldwide, affecting almost half a billion people
each year. Increasing antibiotic resistance and limited therapeutic options have led to the …

[HTML][HTML] Phage therapy—challenges, opportunities and future prospects

B Zalewska-Piątek - Pharmaceuticals, 2023 - mdpi.com
The increasing drug resistance of bacteria to commonly used antibiotics creates the need to
search for and develop alternative forms of treatment. Phage therapy fits this trend perfectly …