Developing phage therapy that overcomes the evolution of bacterial resistance
A Oromí-Bosch, JD Antani… - Annual Review of Virology, 2023 - annualreviews.org
The global rise of antibiotic resistance in bacterial pathogens and the waning efficacy of
antibiotics urge consideration of alternative antimicrobial strategies. Phage therapy is a …
antibiotics urge consideration of alternative antimicrobial strategies. Phage therapy is a …
Emergent crisis of antibiotic resistance: A silent pandemic threat to 21st century
Antibiotic resistance has become an indispensably alarming menace to the global
community. The primary factors are overuse and abuse of antibiotics, lack of novel …
community. The primary factors are overuse and abuse of antibiotics, lack of novel …
[HTML][HTML] Antimicrobial resistance and recent alternatives to antibiotics for the control of bacterial pathogens with an emphasis on foodborne pathogens
Antimicrobial resistance (AMR) is one of the most important global public health problems.
The imprudent use of antibiotics in humans and animals has resulted in the emergence of …
The imprudent use of antibiotics in humans and animals has resulted in the emergence of …
[HTML][HTML] The future of clinical phage therapy in the United Kingdom
JD Jones, C Trippett, M Suleman, MRJ Clokie, JR Clark - Viruses, 2023 - mdpi.com
Bacteriophage (phage) therapy is a promising alternative antimicrobial strategy with the
potential to transform the way bacterial infections are treated. In the United Kingdom, phages …
potential to transform the way bacterial infections are treated. In the United Kingdom, phages …
[HTML][HTML] L-form conversion in Gram-positive bacteria enables escape from phage infection
JC Wohlfarth, M Feldmüller, A Schneller, S Kilcher… - Nature …, 2023 - nature.com
At the end of a lytic bacteriophage replication cycle in Gram-positive bacteria, peptidoglycan-
degrading endolysins that cause explosive cell lysis of the host can also attack non-infected …
degrading endolysins that cause explosive cell lysis of the host can also attack non-infected …
[HTML][HTML] A century of clinical use of phages: a literature review
K Diallo, A Dublanchet - Antibiotics, 2023 - mdpi.com
Growing antibiotic resistance and the broken antibiotic market have renewed interest in the
use of phages, a century-old therapy that fell into oblivion in the West after two decades of …
use of phages, a century-old therapy that fell into oblivion in the West after two decades of …
[HTML][HTML] Immunogenicity of CRISPR therapeutics—Critical considerations for clinical translation
R Ewaisha, KS Anderson - Frontiers in Bioengineering and …, 2023 - frontiersin.org
CRISPR offers new hope for many patients and promises to transform the way we think of
future therapies. Ensuring safety of CRISPR therapeutics is a top priority for clinical …
future therapies. Ensuring safety of CRISPR therapeutics is a top priority for clinical …
The current status of phage therapy and its advancement towards establishing standard antimicrobials for combating multi drug-resistant bacterial pathogens
Phage therapy; a revived antimicrobial weapon, has great therapeutic advantages with the
main ones being its ability to eradicate multidrug-resistant pathogens as well as selective …
main ones being its ability to eradicate multidrug-resistant pathogens as well as selective …
Phage therapy in the management of urinary tract infections: a comprehensive systematic review
AM Al-Anany, PB Hooey, JD Cook, LL Burrows… - Phage, 2023 - liebertpub.com
Urinary tract infections (UTIs) are a problem worldwide, affecting almost half a billion people
each year. Increasing antibiotic resistance and limited therapeutic options have led to the …
each year. Increasing antibiotic resistance and limited therapeutic options have led to the …
[HTML][HTML] Phage therapy—challenges, opportunities and future prospects
B Zalewska-Piątek - Pharmaceuticals, 2023 - mdpi.com
The increasing drug resistance of bacteria to commonly used antibiotics creates the need to
search for and develop alternative forms of treatment. Phage therapy fits this trend perfectly …
search for and develop alternative forms of treatment. Phage therapy fits this trend perfectly …